Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches
Recent advancements in disease modeling for myocardial infarction (MI) and coronary artery disease (CAD) have significantly enhanced our understanding of cardiovascular pathology and therapeutic development. This review comprehensively reviews the integration of in vivo and in vitro approaches to be...
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MDPI AG
2024-10-01
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| author | Riya Kar Debabrata Mukhopadhyay Ramcharan Singh Angom |
| author_facet | Riya Kar Debabrata Mukhopadhyay Ramcharan Singh Angom |
| author_sort | Riya Kar |
| collection | DOAJ |
| description | Recent advancements in disease modeling for myocardial infarction (MI) and coronary artery disease (CAD) have significantly enhanced our understanding of cardiovascular pathology and therapeutic development. This review comprehensively reviews the integration of in vivo and in vitro approaches to better model and study these conditions. We specifically focus on cutting-edge in vitro techniques, such as cardiac organoids, engineered heart tissues, and patient-derived induced pluripotent stem cells (iPSCs), which allow for detailed exploration of cellular and molecular mechanisms involved in MI and CAD. These models provide insights into ischemic injury, myocardial remodeling, and the effects of potential therapeutic interventions at a cellular level. In parallel, we discuss advances in the in vivo models, including genetically modified mice and large animal models, which offer valuable information on disease progression, cardiac function, and response to treatments within a more complex physiological context. By bridging these in vivo and in vitro approaches, researchers can gain a more comprehensive understanding of disease mechanisms, validate experimental findings, and accelerate the development of effective therapies. This review highlights recent progress, identifies current limitations, and proposes strategies for future research to enhance the translation of model-based discoveries into clinical practice for MI and CAD. |
| format | Article |
| id | doaj-art-e8b726f5f11d4a5181efcbdc6cfd65bb |
| institution | DOAJ |
| issn | 2673-3846 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hearts |
| spelling | doaj-art-e8b726f5f11d4a5181efcbdc6cfd65bb2025-08-20T02:55:41ZengMDPI AGHearts2673-38462024-10-015442944710.3390/hearts5040031Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro ApproachesRiya Kar0Debabrata Mukhopadhyay1Ramcharan Singh Angom2Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 4500 San Pablo Road S, Jacksonville, FL 32224, USADepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 4500 San Pablo Road S, Jacksonville, FL 32224, USADepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 4500 San Pablo Road S, Jacksonville, FL 32224, USARecent advancements in disease modeling for myocardial infarction (MI) and coronary artery disease (CAD) have significantly enhanced our understanding of cardiovascular pathology and therapeutic development. This review comprehensively reviews the integration of in vivo and in vitro approaches to better model and study these conditions. We specifically focus on cutting-edge in vitro techniques, such as cardiac organoids, engineered heart tissues, and patient-derived induced pluripotent stem cells (iPSCs), which allow for detailed exploration of cellular and molecular mechanisms involved in MI and CAD. These models provide insights into ischemic injury, myocardial remodeling, and the effects of potential therapeutic interventions at a cellular level. In parallel, we discuss advances in the in vivo models, including genetically modified mice and large animal models, which offer valuable information on disease progression, cardiac function, and response to treatments within a more complex physiological context. By bridging these in vivo and in vitro approaches, researchers can gain a more comprehensive understanding of disease mechanisms, validate experimental findings, and accelerate the development of effective therapies. This review highlights recent progress, identifies current limitations, and proposes strategies for future research to enhance the translation of model-based discoveries into clinical practice for MI and CAD.https://www.mdpi.com/2673-3846/5/4/31myocardial infarction (MI)coronary artery disease (CAD)cardiovascular diseases (CVDs)disease modelingcardiac organoids3D cardiac cultures |
| spellingShingle | Riya Kar Debabrata Mukhopadhyay Ramcharan Singh Angom Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches Hearts myocardial infarction (MI) coronary artery disease (CAD) cardiovascular diseases (CVDs) disease modeling cardiac organoids 3D cardiac cultures |
| title | Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches |
| title_full | Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches |
| title_fullStr | Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches |
| title_full_unstemmed | Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches |
| title_short | Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches |
| title_sort | progress in disease modeling for myocardial infarction and coronary artery disease bridging in vivo and in vitro approaches |
| topic | myocardial infarction (MI) coronary artery disease (CAD) cardiovascular diseases (CVDs) disease modeling cardiac organoids 3D cardiac cultures |
| url | https://www.mdpi.com/2673-3846/5/4/31 |
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