Epigenetic mechanisms linking atherosclerosis to ischemic stroke: insights from DNA methylation and transcriptome integration

Epigenetic mechanisms linking atherosclerosis to ischemic stroke: insights from DNA methylation and transcriptome integration

BackgroundIschemic stroke (IS) is a major cause of mortality and disability, with atherosclerosis (AS) as a primary risk factor. DNA methylation plays a critical role in AS development, but its regulatory mechanisms remain unclear. This study aims to investigate the epigenetic regulatory mechanisms...

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Bibliographic Details
Main Authors: Binrong Ding, Yiqun Wang, Junfeng Li, Xuewei Zhang, Zhengqing Wan, Hao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Genetics
Subjects:
ischemic stroke
atherosclerosis
integrated bioinformatics approaches
DNA methylation
transcriptomics
epigenetic regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1567951/full
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