A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia
Factor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia. Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin. A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombo...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/9098604 |
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| author | Andrew Chu Thu Thu Aung Minni Shreya Arumugam Mauricio Danckers Mohi Mitiek Jonathan Leslie |
| author_facet | Andrew Chu Thu Thu Aung Minni Shreya Arumugam Mauricio Danckers Mohi Mitiek Jonathan Leslie |
| author_sort | Andrew Chu |
| collection | DOAJ |
| description | Factor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia. Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin. A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombosis. FVL mutation associated with right heart thrombus is a rare entity. Right heart thrombus or right heart thrombus-in-transit is associated with high mortality. We present a 51-year-old male with a past medical history of FVL homozygous mutation and recurrent blood clots, who has failed multiple different oral anticoagulants. He presented to the hospital with symptoms of shortness of breath and subsequently found to have a giant right heart thrombus. He was treated with surgical embolectomy. This case underscores the challenges faced by patients with FVL and recurrent blood clots. |
| format | Article |
| id | doaj-art-e8b618f830db4592a342a1ac7f2498da |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-e8b618f830db4592a342a1ac7f2498da2025-02-03T05:52:18ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/90986049098604A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden ThrombophiliaAndrew Chu0Thu Thu Aung1Minni Shreya Arumugam2Mauricio Danckers3Mohi Mitiek4Jonathan Leslie5Internal Medicine Residency Department, Aventura Hospital and Medical Center, 20900 Biscayne Boulevard, Aventura, FL 33190, USAInternal Medicine Residency Department, Aventura Hospital and Medical Center, 20900 Biscayne Boulevard, Aventura, FL 33190, USAInternal Medicine Residency Department, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USAInternal Medicine Residency Department, Aventura Hospital and Medical Center, 20900 Biscayne Boulevard, Aventura, FL 33190, USAInternal Medicine Residency Department, Aventura Hospital and Medical Center, 20900 Biscayne Boulevard, Aventura, FL 33190, USAInternal Medicine Residency Department, Aventura Hospital and Medical Center, 20900 Biscayne Boulevard, Aventura, FL 33190, USAFactor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia. Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin. A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombosis. FVL mutation associated with right heart thrombus is a rare entity. Right heart thrombus or right heart thrombus-in-transit is associated with high mortality. We present a 51-year-old male with a past medical history of FVL homozygous mutation and recurrent blood clots, who has failed multiple different oral anticoagulants. He presented to the hospital with symptoms of shortness of breath and subsequently found to have a giant right heart thrombus. He was treated with surgical embolectomy. This case underscores the challenges faced by patients with FVL and recurrent blood clots.http://dx.doi.org/10.1155/2018/9098604 |
| spellingShingle | Andrew Chu Thu Thu Aung Minni Shreya Arumugam Mauricio Danckers Mohi Mitiek Jonathan Leslie A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia Case Reports in Hematology |
| title | A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia |
| title_full | A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia |
| title_fullStr | A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia |
| title_full_unstemmed | A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia |
| title_short | A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia |
| title_sort | giant right heart thrombus in transit the challenge of anticoagulation in factor v leiden thrombophilia |
| url | http://dx.doi.org/10.1155/2018/9098604 |
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