Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas
Abstract The histological grade is crucial for therapeutic management, and its reliable preoperative detection can significantly influence treatment approach. Lacking established risk factors, this study identifies preoperative predictors of high-grade skull base meningiomas and discusses the implic...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87882-z |
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| author | Michaela May Vojtech Sedlak Ladislav Pecen Vladimir Priban Pavel Buchvald Jiri Fiedler Miroslav Vaverka Radim Lipina Stefan Reguli Jozef Malik Martin Cerny David Netuka Vladimir Benes |
| author_facet | Michaela May Vojtech Sedlak Ladislav Pecen Vladimir Priban Pavel Buchvald Jiri Fiedler Miroslav Vaverka Radim Lipina Stefan Reguli Jozef Malik Martin Cerny David Netuka Vladimir Benes |
| author_sort | Michaela May |
| collection | DOAJ |
| description | Abstract The histological grade is crucial for therapeutic management, and its reliable preoperative detection can significantly influence treatment approach. Lacking established risk factors, this study identifies preoperative predictors of high-grade skull base meningiomas and discusses the implications of non-invasive detection. A multicentric study was conducted on 552 patients with skull base meningiomas who underwent primary surgical resection between 2014 and 2019. Data were gathered from clinical, surgical and pathology records and radiological diagnostics. The predictive factors of higher WHO grade were analysed in univariate analysis and multivariate stepwise selection logistic regression analysis. Histological analysis revealed 511 grade 1 (92.6%) and 41 grade 2 (7.4%) meningiomas. A prognostic model predicting the probability of WHO grade 2 skull base meningioma (AUC 0.79; SE 0.04; 95% Wald Confidence Limits (0.71; 0.86)) based on meningioma diameter, presence of an arachnoid plane and cranial nerve palsy was built. Accurate preoperative detection of WHO grade in skull base meningiomas is essential for effective treatment planning. Our logistic regression model, based on diameter, cranial nerve palsy, and arachnoid plane, is tailored for detecting WHO grade 2 skull base meningiomas, even in outpatient settings. |
| format | Article |
| id | doaj-art-e8b4517b0d794bbb9f372198f32692c6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e8b4517b0d794bbb9f372198f32692c62025-02-02T12:20:38ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-87882-zRisk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomasMichaela May0Vojtech Sedlak1Ladislav Pecen2Vladimir Priban3Pavel Buchvald4Jiri Fiedler5Miroslav Vaverka6Radim Lipina7Stefan Reguli8Jozef Malik9Martin Cerny10David Netuka11Vladimir Benes12Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University and Military University HospitalDepartment of Radiodiagnostics, Military University HospitalInstitute of Computer Science, The Czech Academy of SciencesDepartment of Neurosurgery, Pilsen University HospitalDepartment of Neurosurgery, Liberec HospitalDepartment of Neurosurgery, Ceske Budejovice HospitalDepartment of Neurosurgery, University Hospital OlomoucDepartment of Neurosurgery, University Hospital OstravaDepartment of Neurosurgery, University Hospital OstravaDepartment of Radiodiagnostics, Military University HospitalDepartment of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University and Military University HospitalDepartment of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University and Military University HospitalDepartment of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University and Military University HospitalAbstract The histological grade is crucial for therapeutic management, and its reliable preoperative detection can significantly influence treatment approach. Lacking established risk factors, this study identifies preoperative predictors of high-grade skull base meningiomas and discusses the implications of non-invasive detection. A multicentric study was conducted on 552 patients with skull base meningiomas who underwent primary surgical resection between 2014 and 2019. Data were gathered from clinical, surgical and pathology records and radiological diagnostics. The predictive factors of higher WHO grade were analysed in univariate analysis and multivariate stepwise selection logistic regression analysis. Histological analysis revealed 511 grade 1 (92.6%) and 41 grade 2 (7.4%) meningiomas. A prognostic model predicting the probability of WHO grade 2 skull base meningioma (AUC 0.79; SE 0.04; 95% Wald Confidence Limits (0.71; 0.86)) based on meningioma diameter, presence of an arachnoid plane and cranial nerve palsy was built. Accurate preoperative detection of WHO grade in skull base meningiomas is essential for effective treatment planning. Our logistic regression model, based on diameter, cranial nerve palsy, and arachnoid plane, is tailored for detecting WHO grade 2 skull base meningiomas, even in outpatient settings.https://doi.org/10.1038/s41598-025-87882-zMeningiomaSkull baseSurgeryTumor gradingRisk factorsCase series |
| spellingShingle | Michaela May Vojtech Sedlak Ladislav Pecen Vladimir Priban Pavel Buchvald Jiri Fiedler Miroslav Vaverka Radim Lipina Stefan Reguli Jozef Malik Martin Cerny David Netuka Vladimir Benes Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas Scientific Reports Meningioma Skull base Surgery Tumor grading Risk factors Case series |
| title | Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas |
| title_full | Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas |
| title_fullStr | Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas |
| title_full_unstemmed | Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas |
| title_short | Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas |
| title_sort | risk factors associated with higher who grade in meningiomas a multicentric study of 552 skull base meningiomas |
| topic | Meningioma Skull base Surgery Tumor grading Risk factors Case series |
| url | https://doi.org/10.1038/s41598-025-87882-z |
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