Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide

A simple, sensitive spectrophotometric method for the determination of Famciclovir and Racecodotril is developed. It is based on the formation of a colored oxidative coupling product between 2,6-dichloroquinone-chlorimide and the drug is described. The method has been extended to pharmaceutical prep...

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Main Authors: M. Vamsi Krishna, P. V. Madhavi Latha, D. Gowri Sankar
Format: Article
Language:English
Published: Wiley 2007-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2007/473705
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author M. Vamsi Krishna
P. V. Madhavi Latha
D. Gowri Sankar
author_facet M. Vamsi Krishna
P. V. Madhavi Latha
D. Gowri Sankar
author_sort M. Vamsi Krishna
collection DOAJ
description A simple, sensitive spectrophotometric method for the determination of Famciclovir and Racecodotril is developed. It is based on the formation of a colored oxidative coupling product between 2,6-dichloroquinone-chlorimide and the drug is described. The method has been extended to pharmaceutical preparations. The absorption maxima and Beer’s law limits for Famciclovir are 500 nm, 20-100 µg/mL and for Racecodotril are 460 nm, 12.5-62.5 µg/mL.
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institution Kabale University
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publishDate 2007-01-01
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series E-Journal of Chemistry
spelling doaj-art-e8ae3da19a3e4765998c62959a1285992025-02-03T01:26:32ZengWileyE-Journal of Chemistry0973-49452090-98102007-01-0141505210.1155/2007/473705Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–ChlorimideM. Vamsi Krishna0P. V. Madhavi Latha1D. Gowri Sankar2Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003., IndiaDepartment of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003., IndiaDepartment of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003., IndiaA simple, sensitive spectrophotometric method for the determination of Famciclovir and Racecodotril is developed. It is based on the formation of a colored oxidative coupling product between 2,6-dichloroquinone-chlorimide and the drug is described. The method has been extended to pharmaceutical preparations. The absorption maxima and Beer’s law limits for Famciclovir are 500 nm, 20-100 µg/mL and for Racecodotril are 460 nm, 12.5-62.5 µg/mL.http://dx.doi.org/10.1155/2007/473705
spellingShingle M. Vamsi Krishna
P. V. Madhavi Latha
D. Gowri Sankar
Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide
E-Journal of Chemistry
title Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide
title_full Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide
title_fullStr Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide
title_full_unstemmed Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide
title_short Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide
title_sort spectrophotometric determination of famciclovir and racecodotril using 2 6 dichloroquinone chlorimide
url http://dx.doi.org/10.1155/2007/473705
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