Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease
Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potenti...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/9638797 |
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| author | Branka Filipović Olivera Marković Vesna Đurić Branislav Filipović |
| author_facet | Branka Filipović Olivera Marković Vesna Đurić Branislav Filipović |
| author_sort | Branka Filipović |
| collection | DOAJ |
| description | Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potentials have also been reported, both in patient related and in animal model-based investigations, and correlated with assessed brain tissue changes. We hypothesized that NAFLD, as a condition, affects the brain tissue and, subsequently, the cognitive state. So we compared findings in 40 NAFLD positive and 36 NAFLD negative patients and correlated their brain tissue volumes with the results of Montreal Cognitive Assessment (MoCA) test. Binomial logistic regression verified the influence of NAFLD state leading to lower cognitive potentials: odds ratio 0.096; 95% confidence interval (CI) 0.032–0.289; p<0.001. Patients with NAFLD had a greater risk to suffer from the cognitive impairment and depression: RR = 3.9; 95% CI 1.815–8.381; p=0.0005 and RR = 1.65; 95% CI 1.16–2.36; p=0.006. NAFLD significantly influenced the cognitive deficit and tissue volume reduction and patients suffering from NAFLD had about four times higher risk of having a cognitive impairment. |
| format | Article |
| id | doaj-art-e8ab52a5e078427fb42fae7dba6d0c8f |
| institution | OA Journals |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-e8ab52a5e078427fb42fae7dba6d0c8f2025-08-20T02:22:01ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/96387979638797Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver DiseaseBranka Filipović0Olivera Marković1Vesna Đurić2Branislav Filipović3Faculty of Medicine, University of Belgrade, Dr Subotića Starijeg 8, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Dr Subotića Starijeg 8, Belgrade, SerbiaClinical and Hospital Center “Dr Dragiša Mišović-Dedinje”, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Dr Subotića Starijeg 8, Belgrade, SerbiaStudies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potentials have also been reported, both in patient related and in animal model-based investigations, and correlated with assessed brain tissue changes. We hypothesized that NAFLD, as a condition, affects the brain tissue and, subsequently, the cognitive state. So we compared findings in 40 NAFLD positive and 36 NAFLD negative patients and correlated their brain tissue volumes with the results of Montreal Cognitive Assessment (MoCA) test. Binomial logistic regression verified the influence of NAFLD state leading to lower cognitive potentials: odds ratio 0.096; 95% confidence interval (CI) 0.032–0.289; p<0.001. Patients with NAFLD had a greater risk to suffer from the cognitive impairment and depression: RR = 3.9; 95% CI 1.815–8.381; p=0.0005 and RR = 1.65; 95% CI 1.16–2.36; p=0.006. NAFLD significantly influenced the cognitive deficit and tissue volume reduction and patients suffering from NAFLD had about four times higher risk of having a cognitive impairment.http://dx.doi.org/10.1155/2018/9638797 |
| spellingShingle | Branka Filipović Olivera Marković Vesna Đurić Branislav Filipović Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease Canadian Journal of Gastroenterology and Hepatology |
| title | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
| title_full | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
| title_fullStr | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
| title_short | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
| title_sort | cognitive changes and brain volume reduction in patients with nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2018/9638797 |
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