Genetic variants and clinical determinants affecting the response to 5-Fluorouracil-based treatment in Chilean patients with advanced colorectal cancer

Genetic variants and clinical determinants affecting the response to 5-Fluorouracil-based treatment in Chilean patients with advanced colorectal cancer

BackgroundColorectal cancer is the second most prevalent cancer in Chile, affecting both sexes. Late-stage diagnosis occurs in approximately 25% of cases, with a five-year survival rate of only 14%. Standard treatment involves surgical resection followed by 5-fluorouracil-based chemotherapy, often c...

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Bibliographic Details
Main Authors: Leslie C. Cerpa, Christopher Sandoval, Paula Escalante, Juan P. Cayún, María A. Lavanderos, Claudio Alarcón-Concha, Guillermo Kaempfe, Diego Moreno-Tapia, Camilo S. Quiroz, Carolina Gutierrez-Cáceres, Olga Barajas, Bettina Müller, Alicia Colombo, Gerardo Donoso, Angie Nuñez, Nelson M. Varela, Luis A. Quiñones
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
5-FU
pharmacogenetics
pharmacogenomics
adverse drug reactions
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1589724/full
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