Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020)
Abstract Systemic sclerosis (SSc) is an autoimmune connective tissue disorder that can cause generalized inflammation and is characterized by fibrosis of the skin, organs, and vasculopathy. Limited SSc is more common and typically associated with a milder disease course, whereas diffuse SSc, althoug...
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BMC
2025-05-01
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| Series: | Advances in Rheumatology |
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| Online Access: | https://doi.org/10.1186/s42358-025-00455-6 |
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| author | Julia Jobanputra Nikhil Furtado Ali Bin Abdul Jabbar Danielle B. Dilsaver Noureen Asghar Mohsin Mirza Joseph Nahas Abubakar Tauseef |
| author_facet | Julia Jobanputra Nikhil Furtado Ali Bin Abdul Jabbar Danielle B. Dilsaver Noureen Asghar Mohsin Mirza Joseph Nahas Abubakar Tauseef |
| author_sort | Julia Jobanputra |
| collection | DOAJ |
| description | Abstract Systemic sclerosis (SSc) is an autoimmune connective tissue disorder that can cause generalized inflammation and is characterized by fibrosis of the skin, organs, and vasculopathy. Limited SSc is more common and typically associated with a milder disease course, whereas diffuse SSc, although less common, is linked to a higher mortality rate due to more frequent visceral organ involvement. One of the most common complications of SSc is interstitial lung disease (ILD). ILD is characterized by fibrosis, scarring, and inflammation of the lungs. ILD has a 30% prevalence and a 40% 10-year mortality in patients with SSc worldwide. Hospitalizations for SSc from 2002 to 2020 were obtained using the National Inpatient Sample (NIS), an all-payer administrative database that captures 97% of hospital discharges in the United States. The primary aim was to evaluate whether inpatient mortality, length of stay (LOS), and hospital cost differed if SSc patients had underlying ILD. We estimated multivariable logistic regression and log-normal models controlling for age, biological sex, race/ethnicity, income, and hospital setting. ILD was associated with 88% greater adjusted odds of inpatient mortality (aOR 95% CI: 1.53 to 2.31, p < 0.001), 15% longer stays (aOR 95% CI: 1.04 to 1.28, p = 0.001), and 33% higher adjusted hospital costs (aOR 95% CI: 1.26 to 1.40, p < 0.001). These findings suggest that SSc-ILD has a significant impact on hospitalization outcomes. |
| format | Article |
| id | doaj-art-e8a3ef01db994f70abdedddfa94e32f8 |
| institution | DOAJ |
| issn | 2523-3106 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj-art-e8a3ef01db994f70abdedddfa94e32f82025-08-20T03:10:31ZengBMCAdvances in Rheumatology2523-31062025-05-016511910.1186/s42358-025-00455-6Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020)Julia Jobanputra0Nikhil Furtado1Ali Bin Abdul Jabbar2Danielle B. Dilsaver3Noureen Asghar4Mohsin Mirza5Joseph Nahas6Abubakar Tauseef7School of Medicine, Creighton UniversitySchool of Medicine, Creighton UniversityDepartment of Medicine, School of Medicine, Creighton UniversityDepartment of Clinical Research and Public Health, School of Medicine, Creighton UniversityDepartment of Medicine, School of Medicine, Creighton UniversityDepartment of Medicine, School of Medicine, Creighton UniversityDepartment of Medicine, School of Medicine, Creighton UniversityDepartment of Medicine, School of Medicine, Creighton UniversityAbstract Systemic sclerosis (SSc) is an autoimmune connective tissue disorder that can cause generalized inflammation and is characterized by fibrosis of the skin, organs, and vasculopathy. Limited SSc is more common and typically associated with a milder disease course, whereas diffuse SSc, although less common, is linked to a higher mortality rate due to more frequent visceral organ involvement. One of the most common complications of SSc is interstitial lung disease (ILD). ILD is characterized by fibrosis, scarring, and inflammation of the lungs. ILD has a 30% prevalence and a 40% 10-year mortality in patients with SSc worldwide. Hospitalizations for SSc from 2002 to 2020 were obtained using the National Inpatient Sample (NIS), an all-payer administrative database that captures 97% of hospital discharges in the United States. The primary aim was to evaluate whether inpatient mortality, length of stay (LOS), and hospital cost differed if SSc patients had underlying ILD. We estimated multivariable logistic regression and log-normal models controlling for age, biological sex, race/ethnicity, income, and hospital setting. ILD was associated with 88% greater adjusted odds of inpatient mortality (aOR 95% CI: 1.53 to 2.31, p < 0.001), 15% longer stays (aOR 95% CI: 1.04 to 1.28, p = 0.001), and 33% higher adjusted hospital costs (aOR 95% CI: 1.26 to 1.40, p < 0.001). These findings suggest that SSc-ILD has a significant impact on hospitalization outcomes.https://doi.org/10.1186/s42358-025-00455-6Systemic sclerosisInterstitial lung diseaseMortalityLength of stayHospitalizationsHealthcare costs |
| spellingShingle | Julia Jobanputra Nikhil Furtado Ali Bin Abdul Jabbar Danielle B. Dilsaver Noureen Asghar Mohsin Mirza Joseph Nahas Abubakar Tauseef Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020) Advances in Rheumatology Systemic sclerosis Interstitial lung disease Mortality Length of stay Hospitalizations Healthcare costs |
| title | Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020) |
| title_full | Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020) |
| title_fullStr | Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020) |
| title_full_unstemmed | Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020) |
| title_short | Influence of interstitial lung disease on systemic sclerosis hospitalizations, a national study (2002–2020) |
| title_sort | influence of interstitial lung disease on systemic sclerosis hospitalizations a national study 2002 2020 |
| topic | Systemic sclerosis Interstitial lung disease Mortality Length of stay Hospitalizations Healthcare costs |
| url | https://doi.org/10.1186/s42358-025-00455-6 |
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