Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair
In this study, the efficacy of Lycium barbarum L.-derived exosome-like nanovesicles (LB-EVs) in reinforcing skin barrier function were evaluated. Using a 3D skin model, expression levels of skin barrier proteins such as filaggrin, loricrin and claudin-1 were found to be modulated favorably upon trea...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041725000083 |
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| author | Ye Zhang Bo Zhao Jing Wang Zeyi Zhang Meiping Shen Chengjie Ren Mimi Li Melanie Liu Zhicheng You Ping Li |
| author_facet | Ye Zhang Bo Zhao Jing Wang Zeyi Zhang Meiping Shen Chengjie Ren Mimi Li Melanie Liu Zhicheng You Ping Li |
| author_sort | Ye Zhang |
| collection | DOAJ |
| description | In this study, the efficacy of Lycium barbarum L.-derived exosome-like nanovesicles (LB-EVs) in reinforcing skin barrier function were evaluated. Using a 3D skin model, expression levels of skin barrier proteins such as filaggrin, loricrin and claudin-1 were found to be modulated favorably upon treatment with LB-EVs, suggesting a role in maintaining cutaneous homeostasis. Additionally, we observed upregulated aquaporin 3 (AQP3) expression and increased natural moisturizing factor (NMF) components, indicating improved skin hydration. A split-face clinical trial involving individuals with sensitive skin revealed that incorporating LB-EVs into a cosmetic serum matrix led to reduced facial redness and transepidermal water loss (TEWL) compared to the control group. Two-photon imaging further demonstrated thickening of the stratum corneum on the treated side after 14 days of application, suggesting enhanced barrier integrity. The findings from this study highlight the potential of LB-EVs to fortify the skin's protective barrier, providing a novel therapeutic strategy for the management of photodamage and the enhancement of skin health. |
| format | Article |
| id | doaj-art-e8a2bb4e52564d50ba788629f6209459 |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-e8a2bb4e52564d50ba788629f62094592025-08-20T03:45:08ZengElsevierExtracellular Vesicle2773-04172025-06-01510007210.1016/j.vesic.2025.100072Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repairYe Zhang0Bo Zhao1Jing Wang2Zeyi Zhang3Meiping Shen4Chengjie Ren5Mimi Li6Melanie Liu7Zhicheng You8Ping Li9MelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaMelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaCorresponding author. MelJen Biotechnology (Shanghai) Ltd., South Area, 1st Floor, Building 1, 159 Cailun Road, China (Shanghai) Pilot Free Trade Zone, 201210, Shanghai, China.; MelJen Biotechnology (Shanghai) Ltd., Shanghai, ChinaIn this study, the efficacy of Lycium barbarum L.-derived exosome-like nanovesicles (LB-EVs) in reinforcing skin barrier function were evaluated. Using a 3D skin model, expression levels of skin barrier proteins such as filaggrin, loricrin and claudin-1 were found to be modulated favorably upon treatment with LB-EVs, suggesting a role in maintaining cutaneous homeostasis. Additionally, we observed upregulated aquaporin 3 (AQP3) expression and increased natural moisturizing factor (NMF) components, indicating improved skin hydration. A split-face clinical trial involving individuals with sensitive skin revealed that incorporating LB-EVs into a cosmetic serum matrix led to reduced facial redness and transepidermal water loss (TEWL) compared to the control group. Two-photon imaging further demonstrated thickening of the stratum corneum on the treated side after 14 days of application, suggesting enhanced barrier integrity. The findings from this study highlight the potential of LB-EVs to fortify the skin's protective barrier, providing a novel therapeutic strategy for the management of photodamage and the enhancement of skin health.http://www.sciencedirect.com/science/article/pii/S2773041725000083Lycium barbarum L.Exosome-like nanovesiclesSkin barrierPhotodamageSkin hydration |
| spellingShingle | Ye Zhang Bo Zhao Jing Wang Zeyi Zhang Meiping Shen Chengjie Ren Mimi Li Melanie Liu Zhicheng You Ping Li Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair Extracellular Vesicle Lycium barbarum L. Exosome-like nanovesicles Skin barrier Photodamage Skin hydration |
| title | Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair |
| title_full | Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair |
| title_fullStr | Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair |
| title_full_unstemmed | Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair |
| title_short | Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair |
| title_sort | therapeutic potential of lycium barbarum derived exosome like nanovesicles in combating photodamage and enhancing skin barrier repair |
| topic | Lycium barbarum L. Exosome-like nanovesicles Skin barrier Photodamage Skin hydration |
| url | http://www.sciencedirect.com/science/article/pii/S2773041725000083 |
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