Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial
Summary: Background & Aims: Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder that affects women of reproductive age worldwide. Important metabolic alterations, hyperglycemia, insulin resistance (IR), and impaired glucose metabolism aggravate PCOS, especially in thos...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268525000609 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849713184319995904 |
|---|---|
| author | Fernanda Freitas Pereira Miriam Verginia Lourenço Gabriel Vendruscolo Pizo Beatris Gomes Siqueira Rita M. Moraes Charles L. Cantrell Mei Wang Rosana Maria dos Reis Anderson Marliere Navarro |
| author_facet | Fernanda Freitas Pereira Miriam Verginia Lourenço Gabriel Vendruscolo Pizo Beatris Gomes Siqueira Rita M. Moraes Charles L. Cantrell Mei Wang Rosana Maria dos Reis Anderson Marliere Navarro |
| author_sort | Fernanda Freitas Pereira |
| collection | DOAJ |
| description | Summary: Background & Aims: Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder that affects women of reproductive age worldwide. Important metabolic alterations, hyperglycemia, insulin resistance (IR), and impaired glucose metabolism aggravate PCOS, especially in those who are overweight and obese. Certain root vegetables, such as the tuberous root of yacon (Smallanthus sonchifolius), shows potential antidiabetic activity for improving human health. This study evaluates the effect of yacon syrup on postprandial blood glucose response in overweight or obese women with PCOS. Methods: We conducted a randomized crossover trial lasting fifteen days, with 5 days of intervention and a washout period of 3 days, involving 20 patients diagnosed as overweight or obese with PCOS. We performed a biochemical and anthropometric evaluation of daily food consumption. Yacon syrup and placebo were administered at breakfast, lunch, and dinner. We monitored blood glucose pre-meal, immediate post-meal, 1 hour post-meal, and 2 hours post-meal. A total of 20 women with PCOS were evaluated: 60% (n=12) overweight and 40% (n=8) obese, with a mean age of 27.15 (±5.92) years. Results: There were no significant differences in food consumption (P < 0.05). However, blood glucose data revealed differences in immediate postprandial blood glucose at meals in general (P = 0.007) and in immediate postprandial blood glucose at breakfast and dinner (P= 0.03 and P = 0.034, respectively). Conclusion: The findings suggest that the consumption of yacon syrup as part of meals in overweight or obese women with PCOS may contribute to moderating immediate postprandial glycemic response. This effect could be beneficial in reducing glucose fluctuations following meals. Clinical Trial Registry Number: RBR-104qgt7b. |
| format | Article |
| id | doaj-art-e8a23e721e9a451bbffd5f289f3c56e4 |
| institution | DOAJ |
| issn | 2667-2685 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-e8a23e721e9a451bbffd5f289f3c56e42025-08-20T03:14:01ZengElsevierClinical Nutrition Open Science2667-26852025-08-0162798810.1016/j.nutos.2025.05.011Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trialFernanda Freitas Pereira0Miriam Verginia Lourenço1Gabriel Vendruscolo Pizo2Beatris Gomes Siqueira3Rita M. Moraes4Charles L. Cantrell5Mei Wang6Rosana Maria dos Reis7Anderson Marliere Navarro8Division of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, Graduate Program in Nutrition and Metabolism, University of São Paulo, Ribeirão Preto, BrazilYacon-BR, Research and Development in Natural Products Ltda, Brazil; Corresponding author. Yacon-BR, Research and Development in Natural Products Ltda, Rodovia Prefeito Antônio Duarte Nogueira, 850 - Km 317, contorno Sul, Ribeirão Preto, CEP 14031-800, Brazil.Division of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, Graduate Program in Nutrition and Metabolism, University of São Paulo, Ribeirão Preto, BrazilSanta Martha Agro Ltda, Rodovia Prefeito Antônio Duarte Nogueira Km 317, Contorno Sul, Ribeirão Preto, CEP 14032-800, BrazilYacon-BR, Research and Development in Natural Products Ltda, Brazil; Santa Martha Agro Ltda, Rodovia Prefeito Antônio Duarte Nogueira Km 317, Contorno Sul, Ribeirão Preto, CEP 14032-800, BrazilNatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture, University, MS, USANatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture, University, MS, USADepartment of Gynecology and Obstetrics (DGO), Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), BrazilDivision of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, Graduate Program in Nutrition and Metabolism, University of São Paulo, Ribeirão Preto, BrazilSummary: Background & Aims: Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder that affects women of reproductive age worldwide. Important metabolic alterations, hyperglycemia, insulin resistance (IR), and impaired glucose metabolism aggravate PCOS, especially in those who are overweight and obese. Certain root vegetables, such as the tuberous root of yacon (Smallanthus sonchifolius), shows potential antidiabetic activity for improving human health. This study evaluates the effect of yacon syrup on postprandial blood glucose response in overweight or obese women with PCOS. Methods: We conducted a randomized crossover trial lasting fifteen days, with 5 days of intervention and a washout period of 3 days, involving 20 patients diagnosed as overweight or obese with PCOS. We performed a biochemical and anthropometric evaluation of daily food consumption. Yacon syrup and placebo were administered at breakfast, lunch, and dinner. We monitored blood glucose pre-meal, immediate post-meal, 1 hour post-meal, and 2 hours post-meal. A total of 20 women with PCOS were evaluated: 60% (n=12) overweight and 40% (n=8) obese, with a mean age of 27.15 (±5.92) years. Results: There were no significant differences in food consumption (P < 0.05). However, blood glucose data revealed differences in immediate postprandial blood glucose at meals in general (P = 0.007) and in immediate postprandial blood glucose at breakfast and dinner (P= 0.03 and P = 0.034, respectively). Conclusion: The findings suggest that the consumption of yacon syrup as part of meals in overweight or obese women with PCOS may contribute to moderating immediate postprandial glycemic response. This effect could be beneficial in reducing glucose fluctuations following meals. Clinical Trial Registry Number: RBR-104qgt7b.http://www.sciencedirect.com/science/article/pii/S2667268525000609Polycystic ovary syndromeOverweightObesityPostprandial glycemiaYacon syrupFructooligosaccharides |
| spellingShingle | Fernanda Freitas Pereira Miriam Verginia Lourenço Gabriel Vendruscolo Pizo Beatris Gomes Siqueira Rita M. Moraes Charles L. Cantrell Mei Wang Rosana Maria dos Reis Anderson Marliere Navarro Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial Clinical Nutrition Open Science Polycystic ovary syndrome Overweight Obesity Postprandial glycemia Yacon syrup Fructooligosaccharides |
| title | Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial |
| title_full | Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial |
| title_fullStr | Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial |
| title_full_unstemmed | Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial |
| title_short | Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial |
| title_sort | effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome a double blind randomized clinical trial |
| topic | Polycystic ovary syndrome Overweight Obesity Postprandial glycemia Yacon syrup Fructooligosaccharides |
| url | http://www.sciencedirect.com/science/article/pii/S2667268525000609 |
| work_keys_str_mv | AT fernandafreitaspereira effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT miriamverginialourenco effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT gabrielvendruscolopizo effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT beatrisgomessiqueira effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT ritammoraes effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT charleslcantrell effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT meiwang effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT rosanamariadosreis effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial AT andersonmarlierenavarro effectsofyaconsyruponpostprandialbloodglucoseinwomenwithpolycysticovarysyndromeadoubleblindrandomizedclinicaltrial |