Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach Syndrome
Background: Precocious puberty (PP) is common in children and manifests commonly with increased linear growth. Van Wyk–Grumbach (VWG) syndrome is a rare cause of PP with short stature and delayed bone age. Clinical Description: An 11-year-old girl presented with early menarche, menorrhagia, and stun...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Indian Pediatrics Case Reports |
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| Online Access: | https://journals.lww.com/10.4103/ipcares.ipcares_35_24 |
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| author | Mansi Jain Lavina Patnaik Pragya Mangla Nishant Raizada |
| author_facet | Mansi Jain Lavina Patnaik Pragya Mangla Nishant Raizada |
| author_sort | Mansi Jain |
| collection | DOAJ |
| description | Background:
Precocious puberty (PP) is common in children and manifests commonly with increased linear growth. Van Wyk–Grumbach (VWG) syndrome is a rare cause of PP with short stature and delayed bone age.
Clinical Description:
An 11-year-old girl presented with early menarche, menorrhagia, and stunted height. Examination revealed pallor, dry skin, absence of axillary and pubic hair, and the presence of breast development (Tanner stage 3). A magnetic resonance imaging of the brain by a primary physician revealed a pituitary mass and was referred to neurosurgery, who, however, referred the child to us endocrinologists.
Management and Outcome:
Standard protocol-wise approach showed short stature with delayed bone age, high levels of thyroid-stimulating hormone, follicle-stimulating hormone and prolactin, raised antithyroid peroxidase antibodies along with multicystic ovaries bilaterally, thus cliniching the diagnosis of VWG Syndrome. The patient was started on levothyroxine and showed remission of symptoms and normalization of thyroid function tests as well as pituitary size.
Conclusion:
It is important to be aware that VWG syndrome may be a cause of PP in which the increase in size of the pituitary is reversible with initiation of thyroxine therapy along with complete resolution of all symptoms, avoiding unnecessary surgical interventions. |
| format | Article |
| id | doaj-art-e8a1ff4fa25445c598d63eb8e813589f |
| institution | OA Journals |
| issn | 2772-5170 2772-5189 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Pediatrics Case Reports |
| spelling | doaj-art-e8a1ff4fa25445c598d63eb8e813589f2025-08-20T02:22:10ZengWolters Kluwer Medknow PublicationsIndian Pediatrics Case Reports2772-51702772-51892024-11-014423023310.4103/ipcares.ipcares_35_24Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach SyndromeMansi JainLavina PatnaikPragya ManglaNishant RaizadaBackground: Precocious puberty (PP) is common in children and manifests commonly with increased linear growth. Van Wyk–Grumbach (VWG) syndrome is a rare cause of PP with short stature and delayed bone age. Clinical Description: An 11-year-old girl presented with early menarche, menorrhagia, and stunted height. Examination revealed pallor, dry skin, absence of axillary and pubic hair, and the presence of breast development (Tanner stage 3). A magnetic resonance imaging of the brain by a primary physician revealed a pituitary mass and was referred to neurosurgery, who, however, referred the child to us endocrinologists. Management and Outcome: Standard protocol-wise approach showed short stature with delayed bone age, high levels of thyroid-stimulating hormone, follicle-stimulating hormone and prolactin, raised antithyroid peroxidase antibodies along with multicystic ovaries bilaterally, thus cliniching the diagnosis of VWG Syndrome. The patient was started on levothyroxine and showed remission of symptoms and normalization of thyroid function tests as well as pituitary size. Conclusion: It is important to be aware that VWG syndrome may be a cause of PP in which the increase in size of the pituitary is reversible with initiation of thyroxine therapy along with complete resolution of all symptoms, avoiding unnecessary surgical interventions.https://journals.lww.com/10.4103/ipcares.ipcares_35_24multicystic ovariespituitarythyroid-stimulating hormone |
| spellingShingle | Mansi Jain Lavina Patnaik Pragya Mangla Nishant Raizada Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach Syndrome Indian Pediatrics Case Reports multicystic ovaries pituitary thyroid-stimulating hormone |
| title | Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach Syndrome |
| title_full | Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach Syndrome |
| title_fullStr | Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach Syndrome |
| title_full_unstemmed | Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach Syndrome |
| title_short | Precocious Puberty with Short Stature in a Girl: A Rare Case of Van Wyk–Grumbach Syndrome |
| title_sort | precocious puberty with short stature in a girl a rare case of van wyk grumbach syndrome |
| topic | multicystic ovaries pituitary thyroid-stimulating hormone |
| url | https://journals.lww.com/10.4103/ipcares.ipcares_35_24 |
| work_keys_str_mv | AT mansijain precociouspubertywithshortstatureinagirlararecaseofvanwykgrumbachsyndrome AT lavinapatnaik precociouspubertywithshortstatureinagirlararecaseofvanwykgrumbachsyndrome AT pragyamangla precociouspubertywithshortstatureinagirlararecaseofvanwykgrumbachsyndrome AT nishantraizada precociouspubertywithshortstatureinagirlararecaseofvanwykgrumbachsyndrome |