Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin Aging
Photoaging, predominantly induced by ultraviolet radiation, is a primary driver of premature skin aging, characterized by complex molecular mechanisms including oxidative stress, inflammation, matrix metalloproteinase activation, and extracellular matrix degradation. Consequently, there is growing s...
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2025-07-01
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| author | Jia-Ling Lyu Po-Yuan Wu Hsiao-Fang Liao Chia-Lin Lee Kuo-Ching Wen Chang-Cheng Chang Hsiu-Mei Chiang |
| author_facet | Jia-Ling Lyu Po-Yuan Wu Hsiao-Fang Liao Chia-Lin Lee Kuo-Ching Wen Chang-Cheng Chang Hsiu-Mei Chiang |
| author_sort | Jia-Ling Lyu |
| collection | DOAJ |
| description | Photoaging, predominantly induced by ultraviolet radiation, is a primary driver of premature skin aging, characterized by complex molecular mechanisms including oxidative stress, inflammation, matrix metalloproteinase activation, and extracellular matrix degradation. Consequently, there is growing scientific interest in identifying effective natural agents to counteract skin aging and photoaging. Djulis (<i>Chenopodium formosanum</i>), an indigenous Taiwanese pseudocereal from the Amaranthaceae family, has emerged as a promising candidate for skincare applications because of its rich phytochemicals and diverse bioactivities. This review describes the current understanding of the molecular mechanisms underlying photoaging and examines the therapeutic potential of djulis extract as a multifunctional agent for skin aging. Its mechanisms of action include enhancing antioxidant defenses, modulating inflammatory pathways, preserving the extracellular matrix, and inhibiting the formation of advanced glycation end products. Bioactive constituents of djulis extract, including phenolic compounds, flavonoids, and betanin, are known to exhibit potent antioxidant and photoprotective activities by modulating multiple molecular pathways essential for skin protection. The bioactivities of djulis in in vitro and animal studies, and four skin clinical trials of djulis extract products are presented in this review article. Ultimately, this review provides an overview that supports the potential of djulis extract in the development of evidence-based skincare formulations for the prevention and treatment of skin aging. |
| format | Article |
| id | doaj-art-e8931b5eab48437c8d4651dfda3b4e1c |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-e8931b5eab48437c8d4651dfda3b4e1c2025-08-20T03:02:58ZengMDPI AGMolecules1420-30492025-07-013015320910.3390/molecules30153209Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin AgingJia-Ling Lyu0Po-Yuan Wu1Hsiao-Fang Liao2Chia-Lin Lee3Kuo-Ching Wen4Chang-Cheng Chang5Hsiu-Mei Chiang6Department of Cosmeceutics, China Medical University, Taichung 406, TaiwanSchool of Medicine, China Medical University, Taichung 404, TaiwanDepartment of Cosmeceutics, China Medical University, Taichung 406, TaiwanDepartment of Cosmeceutics, China Medical University, Taichung 406, TaiwanDepartment of Cosmeceutics, China Medical University, Taichung 406, TaiwanDepartment of Cosmeceutics, China Medical University, Taichung 406, TaiwanDepartment of Cosmeceutics, China Medical University, Taichung 406, TaiwanPhotoaging, predominantly induced by ultraviolet radiation, is a primary driver of premature skin aging, characterized by complex molecular mechanisms including oxidative stress, inflammation, matrix metalloproteinase activation, and extracellular matrix degradation. Consequently, there is growing scientific interest in identifying effective natural agents to counteract skin aging and photoaging. Djulis (<i>Chenopodium formosanum</i>), an indigenous Taiwanese pseudocereal from the Amaranthaceae family, has emerged as a promising candidate for skincare applications because of its rich phytochemicals and diverse bioactivities. This review describes the current understanding of the molecular mechanisms underlying photoaging and examines the therapeutic potential of djulis extract as a multifunctional agent for skin aging. Its mechanisms of action include enhancing antioxidant defenses, modulating inflammatory pathways, preserving the extracellular matrix, and inhibiting the formation of advanced glycation end products. Bioactive constituents of djulis extract, including phenolic compounds, flavonoids, and betanin, are known to exhibit potent antioxidant and photoprotective activities by modulating multiple molecular pathways essential for skin protection. The bioactivities of djulis in in vitro and animal studies, and four skin clinical trials of djulis extract products are presented in this review article. Ultimately, this review provides an overview that supports the potential of djulis extract in the development of evidence-based skincare formulations for the prevention and treatment of skin aging.https://www.mdpi.com/1420-3049/30/15/3209<i>Chenopodium formosanum</i>photoagingphytochemicalsantioxidantanti-inflammatorymatrix metalloproteinases |
| spellingShingle | Jia-Ling Lyu Po-Yuan Wu Hsiao-Fang Liao Chia-Lin Lee Kuo-Ching Wen Chang-Cheng Chang Hsiu-Mei Chiang Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin Aging Molecules <i>Chenopodium formosanum</i> photoaging phytochemicals antioxidant anti-inflammatory matrix metalloproteinases |
| title | Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin Aging |
| title_full | Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin Aging |
| title_fullStr | Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin Aging |
| title_full_unstemmed | Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin Aging |
| title_short | Djulis (<i>Chenopodium formosanum</i>) Extract as a Promising Natural Agent Against Skin Aging |
| title_sort | djulis i chenopodium formosanum i extract as a promising natural agent against skin aging |
| topic | <i>Chenopodium formosanum</i> photoaging phytochemicals antioxidant anti-inflammatory matrix metalloproteinases |
| url | https://www.mdpi.com/1420-3049/30/15/3209 |
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