Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women
The objective of this study was to investigate the relationship between serum levels of OPG, TGF-β1, and TGF-β2 and BMD decrease rate (BDR) in native Chinese women. This cross-sectional study was performed on 465 healthy native Chinese women aged 35–80 years. Serum levels of OPG, TGF-β1, and TGF-β2...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/727164 |
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| author | Xi-Yu Wu Yi-Qun Peng Hong Zhang Hui Xie Zhi-Feng Sheng Xiang-Hang Luo Ru-Chun Dai Hou-De Zhou Xian-Ping Wu Er-Yuan Liao |
| author_facet | Xi-Yu Wu Yi-Qun Peng Hong Zhang Hui Xie Zhi-Feng Sheng Xiang-Hang Luo Ru-Chun Dai Hou-De Zhou Xian-Ping Wu Er-Yuan Liao |
| author_sort | Xi-Yu Wu |
| collection | DOAJ |
| description | The objective of this study was to investigate the relationship between serum levels of OPG, TGF-β1, and TGF-β2 and BMD decrease rate (BDR) in native Chinese women. This cross-sectional study was performed on 465 healthy native Chinese women aged 35–80 years. Serum levels of OPG, TGF-β1, and TGF-β2 were determined. BDR was measured by DXA at the posteroanterior spine, hip, and distal forearm. At all skeletal sites tested, there was a negative correlation between BDR and serum levels of both OPG (r=−0.122 to –0.230, all P = 0.007–0.000) and TGF-β2 (r=−0.100 to –0.173, all P = 0.029–0.000) and a positive correlation between BDR and serum TGF-β1 (r=0.245−0.365, all P=0.000). After adjustment for age and BMI, there were no statistically significant correlations between serum levels of OPG or TGF-β2 and BDR. However, statistically significant correlations between serum TGF-β1 and BDR at the lumbar spine and ultradistal forearm remained. Multiple linear regression stepwise analysis showed that serum OPG could explain 1.4–3.7% of BDR variation. Serum TGF-β1 was a positive determinant of BDR and could explain 5.3–13.3% of BDR variation. |
| format | Article |
| id | doaj-art-e88b5f1a4bba443ba8a850fdc095c58c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e88b5f1a4bba443ba8a850fdc095c58c2025-02-03T06:06:18ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/727164727164Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese WomenXi-Yu Wu0Yi-Qun Peng1Hong Zhang2Hui Xie3Zhi-Feng Sheng4Xiang-Hang Luo5Ru-Chun Dai6Hou-De Zhou7Xian-Ping Wu8Er-Yuan Liao9Institute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, ChinaThe objective of this study was to investigate the relationship between serum levels of OPG, TGF-β1, and TGF-β2 and BMD decrease rate (BDR) in native Chinese women. This cross-sectional study was performed on 465 healthy native Chinese women aged 35–80 years. Serum levels of OPG, TGF-β1, and TGF-β2 were determined. BDR was measured by DXA at the posteroanterior spine, hip, and distal forearm. At all skeletal sites tested, there was a negative correlation between BDR and serum levels of both OPG (r=−0.122 to –0.230, all P = 0.007–0.000) and TGF-β2 (r=−0.100 to –0.173, all P = 0.029–0.000) and a positive correlation between BDR and serum TGF-β1 (r=0.245−0.365, all P=0.000). After adjustment for age and BMI, there were no statistically significant correlations between serum levels of OPG or TGF-β2 and BDR. However, statistically significant correlations between serum TGF-β1 and BDR at the lumbar spine and ultradistal forearm remained. Multiple linear regression stepwise analysis showed that serum OPG could explain 1.4–3.7% of BDR variation. Serum TGF-β1 was a positive determinant of BDR and could explain 5.3–13.3% of BDR variation.http://dx.doi.org/10.1155/2013/727164 |
| spellingShingle | Xi-Yu Wu Yi-Qun Peng Hong Zhang Hui Xie Zhi-Feng Sheng Xiang-Hang Luo Ru-Chun Dai Hou-De Zhou Xian-Ping Wu Er-Yuan Liao Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women International Journal of Endocrinology |
| title | Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women |
| title_full | Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women |
| title_fullStr | Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women |
| title_full_unstemmed | Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women |
| title_short | Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women |
| title_sort | relationship between serum levels of opg and tgf β with decreasing rate of bmd in native chinese women |
| url | http://dx.doi.org/10.1155/2013/727164 |
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