Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis
Increasing evidence has suggested that T helper 17 (Th17) cells play a central role in the pathogenesis of ocular immune disease. The association between pathogenic Th17 cells and the development of uveitis has been confirmed in experimental and clinical studies. Several cytokines affect the initiat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6693542 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564511074156544 |
|---|---|
| author | Kailei Guo Xiaomin Zhang |
| author_facet | Kailei Guo Xiaomin Zhang |
| author_sort | Kailei Guo |
| collection | DOAJ |
| description | Increasing evidence has suggested that T helper 17 (Th17) cells play a central role in the pathogenesis of ocular immune disease. The association between pathogenic Th17 cells and the development of uveitis has been confirmed in experimental and clinical studies. Several cytokines affect the initiation and stabilization of the differentiation of Th17 cells. Therefore, understanding the mechanism of related cytokines in the differentiation of Th17 cells is important for exploring the pathogenesis and the potential therapeutic targets of uveitis. This article briefly describes the structures, mechanisms, and targeted drugs of cytokines—including interleukin (IL)-6, transforming growth factor-β1 (TGF-β1), IL-1β, IL-23, IL-27, IL-35, IL-2, IL-4, IL-21, and interferon (IFN)-γ—which have an important influence on the differentiation of Th17 cells and discusses their potential as therapeutic targets for treating autoimmune uveitis. |
| format | Article |
| id | doaj-art-e8893dba3f864ce8b3631079ff5383f4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e8893dba3f864ce8b3631079ff5383f42025-02-03T01:10:53ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/66935426693542Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune UveitisKailei Guo0Xiaomin Zhang1Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, ChinaIncreasing evidence has suggested that T helper 17 (Th17) cells play a central role in the pathogenesis of ocular immune disease. The association between pathogenic Th17 cells and the development of uveitis has been confirmed in experimental and clinical studies. Several cytokines affect the initiation and stabilization of the differentiation of Th17 cells. Therefore, understanding the mechanism of related cytokines in the differentiation of Th17 cells is important for exploring the pathogenesis and the potential therapeutic targets of uveitis. This article briefly describes the structures, mechanisms, and targeted drugs of cytokines—including interleukin (IL)-6, transforming growth factor-β1 (TGF-β1), IL-1β, IL-23, IL-27, IL-35, IL-2, IL-4, IL-21, and interferon (IFN)-γ—which have an important influence on the differentiation of Th17 cells and discusses their potential as therapeutic targets for treating autoimmune uveitis.http://dx.doi.org/10.1155/2021/6693542 |
| spellingShingle | Kailei Guo Xiaomin Zhang Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis Journal of Immunology Research |
| title | Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis |
| title_full | Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis |
| title_fullStr | Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis |
| title_full_unstemmed | Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis |
| title_short | Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis |
| title_sort | cytokines that modulate the differentiation of th17 cells in autoimmune uveitis |
| url | http://dx.doi.org/10.1155/2021/6693542 |
| work_keys_str_mv | AT kaileiguo cytokinesthatmodulatethedifferentiationofth17cellsinautoimmuneuveitis AT xiaominzhang cytokinesthatmodulatethedifferentiationofth17cellsinautoimmuneuveitis |