Enteric coating of granules containing the probiotic Lactobacillus acidophilus
In the present study, a capsule formulation composed of enteric coated granules of Lactobacillus acidophilus ATCC 4962 was developed using Eudragit L30D-55 as enteric polymer. Optimization of the capsule formulation was achieved with a maximum viable cell count after 2 h of incubation in acid medium...
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Sciendo
2014-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0011/acph-2014-0011.xml?format=INT |
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| author | Pyar Hassan Peh Kok-Khiang |
| author_facet | Pyar Hassan Peh Kok-Khiang |
| author_sort | Pyar Hassan |
| collection | DOAJ |
| description | In the present study, a capsule formulation composed of enteric coated granules of Lactobacillus acidophilus ATCC 4962 was developed using Eudragit L30D-55 as enteric polymer. Optimization of the capsule formulation was achieved with a maximum viable cell count after 2 h of incubation in acid medium and disintegration time of 1 h in buffer pH 6.8. The amount of Eudragit L30D-55 in the capsules correlated with gastric juice resistance. The best protective qualities against artificial gastric juice were observed when capsules were prepared from granules composed of L. acidophilus, corn starch, lactose monohydrate, polyvinylpyrrolidone and coated with 12.5 % (m/V) of Eudragit L30D-55. Capsule formulation of L. acidophilus in edible broth medium suspension serves as a cheap alternative to the expensive freeze-drying procedure for preparing L. acidophilus. In addition, the enteric coating using Eudragit L30D-55 could protect probiotics from the acidic gastric environment and enhance the bioactivity of probiotics along with replacement of pathogenic microbes in human intestine |
| format | Article |
| id | doaj-art-e87cab1947f24bbe893ad5c634c0c1ae |
| institution | Kabale University |
| issn | 1330-0075 1846-9558 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e87cab1947f24bbe893ad5c634c0c1ae2025-02-02T12:17:14ZengSciendoActa Pharmaceutica1330-00751846-95582014-06-0164224725610.2478/acph-2014-0011acph-2014-0011Enteric coating of granules containing the probiotic Lactobacillus acidophilusPyar Hassan0Peh Kok-Khiang1School of Pharmaceutical Sciences Universiti Sains Malaysia, 11800 Minden Penang, MalaysiaSchool of Pharmaceutical Sciences Universiti Sains Malaysia, 11800 Minden Penang, MalaysiaIn the present study, a capsule formulation composed of enteric coated granules of Lactobacillus acidophilus ATCC 4962 was developed using Eudragit L30D-55 as enteric polymer. Optimization of the capsule formulation was achieved with a maximum viable cell count after 2 h of incubation in acid medium and disintegration time of 1 h in buffer pH 6.8. The amount of Eudragit L30D-55 in the capsules correlated with gastric juice resistance. The best protective qualities against artificial gastric juice were observed when capsules were prepared from granules composed of L. acidophilus, corn starch, lactose monohydrate, polyvinylpyrrolidone and coated with 12.5 % (m/V) of Eudragit L30D-55. Capsule formulation of L. acidophilus in edible broth medium suspension serves as a cheap alternative to the expensive freeze-drying procedure for preparing L. acidophilus. In addition, the enteric coating using Eudragit L30D-55 could protect probiotics from the acidic gastric environment and enhance the bioactivity of probiotics along with replacement of pathogenic microbes in human intestinehttp://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0011/acph-2014-0011.xml?format=INTLactobacillus acidophilusEudragit L30D-55enteric coatingprobioticviable cells |
| spellingShingle | Pyar Hassan Peh Kok-Khiang Enteric coating of granules containing the probiotic Lactobacillus acidophilus Acta Pharmaceutica Lactobacillus acidophilus Eudragit L30D-55 enteric coating probiotic viable cells |
| title | Enteric coating of granules containing the probiotic Lactobacillus acidophilus |
| title_full | Enteric coating of granules containing the probiotic Lactobacillus acidophilus |
| title_fullStr | Enteric coating of granules containing the probiotic Lactobacillus acidophilus |
| title_full_unstemmed | Enteric coating of granules containing the probiotic Lactobacillus acidophilus |
| title_short | Enteric coating of granules containing the probiotic Lactobacillus acidophilus |
| title_sort | enteric coating of granules containing the probiotic lactobacillus acidophilus |
| topic | Lactobacillus acidophilus Eudragit L30D-55 enteric coating probiotic viable cells |
| url | http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0011/acph-2014-0011.xml?format=INT |
| work_keys_str_mv | AT pyarhassan entericcoatingofgranulescontainingtheprobioticlactobacillusacidophilus AT pehkokkhiang entericcoatingofgranulescontainingtheprobioticlactobacillusacidophilus |