Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study
Purpose There is growing global concern about the shift to earlier onset of puberty among girls; however, the prevalences of precocious and normal variant puberty among Thai girls are uncertain. We conducted a study at King Chulalongkorn Memorial Hospital in Bangkok from 2018 to 2022 (amid the coron...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2025-02-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
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| Online Access: | http://e-apem.org/upload/pdf/apem-2448112-056.pdf |
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| author | Phattariya Yaisilp Nattakarn Numsriskulrat Taninee Sahakitrungruang |
| author_facet | Phattariya Yaisilp Nattakarn Numsriskulrat Taninee Sahakitrungruang |
| author_sort | Phattariya Yaisilp |
| collection | DOAJ |
| description | Purpose There is growing global concern about the shift to earlier onset of puberty among girls; however, the prevalences of precocious and normal variant puberty among Thai girls are uncertain. We conducted a study at King Chulalongkorn Memorial Hospital in Bangkok from 2018 to 2022 (amid the coronavirus disease 2019 pandemic) to investigate the prevalence, characteristics, and treatment of early puberty in a large cohort of Thai girls. Methods The medical records of 583 girls who had been evaluated for early puberty were reviewed. Demographic and clinical characteristics, and treatment approaches were analyzed. Results The analyses found a significant annual increase in evaluations for early signs of puberty (P-value for trend 0.04). The majority (71.2%) of cases were categorized as gonadotropin-releasing-hormone (GnRH)-dependent or central precocious puberty (CPP), with 16 cases showing abnormal brain magnetic resonance imaging findings. Among girls with normal variant puberty, early normal puberty was the most common category (10.5%), followed by premature thelarche (9.5%), slow-progressive precocious puberty (6.6%), and premature adrenarche (2.2%). Median age at presentation, basal luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and bone age differed significantly among groups. Importantly, 97% of girls with CPP received GnRH agonists. Girls with CPP exhibited higher body mass index z-scores and basal LH and FSH compared with those with slow-progressive precocious puberty. Conclusions Our analyses of the prevalence, characteristics, and treatment of early puberty in Thai girls highlighted the impact of obesity on pubertal timing. The findings underscore the need for preventive weight management and country-specific guideline updates to enhance healthcare strategies for young girls. |
| format | Article |
| id | doaj-art-e877e68df52b4c1f9b8d2189b268bb2c |
| institution | Kabale University |
| issn | 2287-1012 2287-1292 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj-art-e877e68df52b4c1f9b8d2189b268bb2c2025-08-20T03:53:27ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922025-02-01301172410.6065/apem.2448112.0561078Clinical and epidemiological insights into early puberty in Thai girls: a 5-year studyPhattariya Yaisilp0Nattakarn Numsriskulrat1Taninee Sahakitrungruang2 Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, Thailand Division of Academic Affairs, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, ThailandPurpose There is growing global concern about the shift to earlier onset of puberty among girls; however, the prevalences of precocious and normal variant puberty among Thai girls are uncertain. We conducted a study at King Chulalongkorn Memorial Hospital in Bangkok from 2018 to 2022 (amid the coronavirus disease 2019 pandemic) to investigate the prevalence, characteristics, and treatment of early puberty in a large cohort of Thai girls. Methods The medical records of 583 girls who had been evaluated for early puberty were reviewed. Demographic and clinical characteristics, and treatment approaches were analyzed. Results The analyses found a significant annual increase in evaluations for early signs of puberty (P-value for trend 0.04). The majority (71.2%) of cases were categorized as gonadotropin-releasing-hormone (GnRH)-dependent or central precocious puberty (CPP), with 16 cases showing abnormal brain magnetic resonance imaging findings. Among girls with normal variant puberty, early normal puberty was the most common category (10.5%), followed by premature thelarche (9.5%), slow-progressive precocious puberty (6.6%), and premature adrenarche (2.2%). Median age at presentation, basal luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and bone age differed significantly among groups. Importantly, 97% of girls with CPP received GnRH agonists. Girls with CPP exhibited higher body mass index z-scores and basal LH and FSH compared with those with slow-progressive precocious puberty. Conclusions Our analyses of the prevalence, characteristics, and treatment of early puberty in Thai girls highlighted the impact of obesity on pubertal timing. The findings underscore the need for preventive weight management and country-specific guideline updates to enhance healthcare strategies for young girls.http://e-apem.org/upload/pdf/apem-2448112-056.pdfearly pubertyprevalenceobesitypubertal timinggirls |
| spellingShingle | Phattariya Yaisilp Nattakarn Numsriskulrat Taninee Sahakitrungruang Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study Annals of Pediatric Endocrinology & Metabolism early puberty prevalence obesity pubertal timing girls |
| title | Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study |
| title_full | Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study |
| title_fullStr | Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study |
| title_full_unstemmed | Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study |
| title_short | Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study |
| title_sort | clinical and epidemiological insights into early puberty in thai girls a 5 year study |
| topic | early puberty prevalence obesity pubertal timing girls |
| url | http://e-apem.org/upload/pdf/apem-2448112-056.pdf |
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