Organoid (3D-cell) cultures in the assessment of cross-species virus transmission

The aim of this review is to characterize the possibilities of using organoid (3D-cell) cultures to assess the ability of viruses for cross-species transmission. Sources from Web of Science, PubMed, Scopus, Elsevier, Google Scholar, and eLIBRARY.RU databases as of February 2025 were used. In a...

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Main Authors: Tatyana A. Kuznetsova, Irina V. Galkina, Sergey P. Kryzhanovsky, Mikhail Yu. Shchelkanov
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2025-07-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
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Online Access:https://microbiol.crie.ru/jour/article/viewFile/18783/1615
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author Tatyana A. Kuznetsova
Irina V. Galkina
Sergey P. Kryzhanovsky
Mikhail Yu. Shchelkanov
author_facet Tatyana A. Kuznetsova
Irina V. Galkina
Sergey P. Kryzhanovsky
Mikhail Yu. Shchelkanov
author_sort Tatyana A. Kuznetsova
collection DOAJ
description The aim of this review is to characterize the possibilities of using organoid (3D-cell) cultures to assess the ability of viruses for cross-species transmission. Sources from Web of Science, PubMed, Scopus, Elsevier, Google Scholar, and eLIBRARY.RU databases as of February 2025 were used. In addition to classical methods of epidemiologic diagnostics and surveillance of viral infections, molecular genetic technologies (polymerase chain reaction and sequencing) are widely used in the epidemiologic surveillance system. As the best world experience shows, the use of organoid (3D-cell) cultures is promising in addressing these issues. This review analyzes data on the use of organoid (3D-cell) cultures of human and animal origin to study immunopathogenesis, as well as to assess the ability of a number of viruses (SARS-CoV-2, influenza, Zika, measles, etc.) for cross-species transmission, which determines their pandemic potential
format Article
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issn 0372-9311
2686-7613
language Russian
publishDate 2025-07-01
publisher Central Research Institute for Epidemiology
record_format Article
series Журнал микробиологии, эпидемиологии и иммунобиологии
spelling doaj-art-e875e8b8fa4a4dbfbb43ad2284a6ec412025-08-20T02:46:40ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132025-07-01102337038010.36233/0372-9311-6282834Organoid (3D-cell) cultures in the assessment of cross-species virus transmissionTatyana A. Kuznetsova0https://orcid.org/0000-0002-4315-6959Irina V. Galkina1https://orcid.org/0000-0001-7000-5833Sergey P. Kryzhanovsky2https://orcid.org/0000-0002-1981-1079Mikhail Yu. Shchelkanov3https://orcid.org/0000-0001-8610-7623G.Р. Somov Institute of Epidemiology and MicrobiologyFar Eastern Federal UniversityFar Eastern Branch of the Russian Academy of SciencesG.Р. Somov Institute of Epidemiology and MicrobiologyThe aim of this review is to characterize the possibilities of using organoid (3D-cell) cultures to assess the ability of viruses for cross-species transmission. Sources from Web of Science, PubMed, Scopus, Elsevier, Google Scholar, and eLIBRARY.RU databases as of February 2025 were used. In addition to classical methods of epidemiologic diagnostics and surveillance of viral infections, molecular genetic technologies (polymerase chain reaction and sequencing) are widely used in the epidemiologic surveillance system. As the best world experience shows, the use of organoid (3D-cell) cultures is promising in addressing these issues. This review analyzes data on the use of organoid (3D-cell) cultures of human and animal origin to study immunopathogenesis, as well as to assess the ability of a number of viruses (SARS-CoV-2, influenza, Zika, measles, etc.) for cross-species transmission, which determines their pandemic potentialhttps://microbiol.crie.ru/jour/article/viewFile/18783/1615revieworganoid (3d-cell) culturesvirusescross-species transmissionepidemiology
spellingShingle Tatyana A. Kuznetsova
Irina V. Galkina
Sergey P. Kryzhanovsky
Mikhail Yu. Shchelkanov
Organoid (3D-cell) cultures in the assessment of cross-species virus transmission
Журнал микробиологии, эпидемиологии и иммунобиологии
review
organoid (3d-cell) cultures
viruses
cross-species transmission
epidemiology
title Organoid (3D-cell) cultures in the assessment of cross-species virus transmission
title_full Organoid (3D-cell) cultures in the assessment of cross-species virus transmission
title_fullStr Organoid (3D-cell) cultures in the assessment of cross-species virus transmission
title_full_unstemmed Organoid (3D-cell) cultures in the assessment of cross-species virus transmission
title_short Organoid (3D-cell) cultures in the assessment of cross-species virus transmission
title_sort organoid 3d cell cultures in the assessment of cross species virus transmission
topic review
organoid (3d-cell) cultures
viruses
cross-species transmission
epidemiology
url https://microbiol.crie.ru/jour/article/viewFile/18783/1615
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AT irinavgalkina organoid3dcellculturesintheassessmentofcrossspeciesvirustransmission
AT sergeypkryzhanovsky organoid3dcellculturesintheassessmentofcrossspeciesvirustransmission
AT mikhailyushchelkanov organoid3dcellculturesintheassessmentofcrossspeciesvirustransmission