Organoid (3D-cell) cultures in the assessment of cross-species virus transmission
The aim of this review is to characterize the possibilities of using organoid (3D-cell) cultures to assess the ability of viruses for cross-species transmission. Sources from Web of Science, PubMed, Scopus, Elsevier, Google Scholar, and eLIBRARY.RU databases as of February 2025 were used. In a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Central Research Institute for Epidemiology
2025-07-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.crie.ru/jour/article/viewFile/18783/1615 |
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| Summary: | The aim of this review is to characterize the possibilities of using organoid (3D-cell) cultures to assess the ability of viruses for cross-species transmission.
Sources from Web of Science, PubMed, Scopus, Elsevier, Google Scholar, and eLIBRARY.RU databases as of February 2025 were used.
In addition to classical methods of epidemiologic diagnostics and surveillance of viral infections, molecular genetic technologies (polymerase chain reaction and sequencing) are widely used in the epidemiologic surveillance system. As the best world experience shows, the use of organoid (3D-cell) cultures is promising in addressing these issues. This review analyzes data on the use of organoid (3D-cell) cultures of human and animal origin to study immunopathogenesis, as well as to assess the ability of a number of viruses (SARS-CoV-2, influenza, Zika, measles, etc.) for cross-species transmission, which determines their pandemic potential |
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| ISSN: | 0372-9311 2686-7613 |