Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells.

Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells.

The MYB transcription factor plays critical roles in normal and malignant haematopoiesis. We previously showed that MYB was a direct activator of FLT3 expression within the context of acute myeloid leukaemia. During normal haematopoiesis, increasing levels of FLT3 expression determine a strict hiera...

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Bibliographic Details
Main Authors: Giacomo Volpe, Mary Clarke, Paloma Garcìa, David Scott Walton, Alexandros Vegiopoulos, Walter Del Pozzo, Laura Patricia O'Neill, Jonathan Frampton, Stéphanie Dumon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0138257
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