Expression of Cyclin D1 in Oral Squamous Cell Carcinoma
Background: Cyclin D1 expression regulates normal cell cycle. Its deregulation or overexpression may cause disruption in the normal cell cycle control and lead to cancer progression. In this study, we aimed to study the expression of cyclin D1 in oral squamous cell carcinoma (OSCC) and find its ass...
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Knowledge E
2021-12-01
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| Series: | Sudan Journal of Medical Sciences |
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| Online Access: | https://knepublishing.com/index.php/SJMS/article/view/9953 |
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| _version_ | 1832592320068845568 |
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| author | Malak Abdulrahman Seid Ahmed Nazik Omer Ahmed M. Suliman Mona Ellaithi |
| author_facet | Malak Abdulrahman Seid Ahmed Nazik Omer Ahmed M. Suliman Mona Ellaithi |
| author_sort | Malak Abdulrahman Seid Ahmed |
| collection | DOAJ |
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Background: Cyclin D1 expression regulates normal cell cycle. Its deregulation or overexpression may cause disruption in the normal cell cycle control and lead to cancer progression. In this study, we aimed to study the expression of cyclin D1 in oral squamous cell carcinoma (OSCC) and find its association with the different grades of oral tumors, if any.
Methods: This cross-sectional study included 40 formalin-fixed paraffin-embedded tissue blocks specimens of OSCC with variable grades. The expression of cyclin D1 was evaluated through immunohistochemical (IHC) staining.
Results: There were 9 female and 31 male samples, with a male-to-female ratio of 3.4:1. The age ranged between 25 and 90 years with an average age of 65.5 years. Twenty-five (62.5%) samples were diagnosed as well-differentiated squamous cell carcinoma (WDSCC) and fifteen (37.5%) as poorly differentiated squamous cell carcinoma (PDSCC). No cases of moderately differentiated squamous carcinoma were included in the study. The expression of cyclin D1 was detected in the cases of WDSCC and a lesser expression was seen in the PDSCC with a P-value of 0.0003, OR 1581 and 95% CI (29.8239 to 83810.7113).
Conclusion: Cyclin D1 is expressed in OSCC and stronger expression was detected in WDSCC.
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| format | Article |
| id | doaj-art-e86f2b6defe84909985416e40d4eda24 |
| institution | Kabale University |
| issn | 1858-5051 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj-art-e86f2b6defe84909985416e40d4eda242025-01-21T11:43:27ZengKnowledge ESudan Journal of Medical Sciences1858-50512021-12-0116410.18502/sjms.v16i4.9953Expression of Cyclin D1 in Oral Squamous Cell CarcinomaMalak Abdulrahman Seid Ahmed0Nazik Omer1Ahmed M. Suliman2Mona Ellaithi3Faculty of Medical Laboratory sciences, Al-Neelain University, Khartoum, SudanDepartment of oral and maxillofacial surgery, division of oral Pathology, Faculty of Dentistry, University of Khartoum, SudanDepartment of oral and maxillofacial surgery, division of oral Pathology, Faculty of Dentistry, University of Khartoum, SudanFaculty of Medical Laboratory sciences, Al-Neelain University, Khartoum, Sudan Background: Cyclin D1 expression regulates normal cell cycle. Its deregulation or overexpression may cause disruption in the normal cell cycle control and lead to cancer progression. In this study, we aimed to study the expression of cyclin D1 in oral squamous cell carcinoma (OSCC) and find its association with the different grades of oral tumors, if any. Methods: This cross-sectional study included 40 formalin-fixed paraffin-embedded tissue blocks specimens of OSCC with variable grades. The expression of cyclin D1 was evaluated through immunohistochemical (IHC) staining. Results: There were 9 female and 31 male samples, with a male-to-female ratio of 3.4:1. The age ranged between 25 and 90 years with an average age of 65.5 years. Twenty-five (62.5%) samples were diagnosed as well-differentiated squamous cell carcinoma (WDSCC) and fifteen (37.5%) as poorly differentiated squamous cell carcinoma (PDSCC). No cases of moderately differentiated squamous carcinoma were included in the study. The expression of cyclin D1 was detected in the cases of WDSCC and a lesser expression was seen in the PDSCC with a P-value of 0.0003, OR 1581 and 95% CI (29.8239 to 83810.7113). Conclusion: Cyclin D1 is expressed in OSCC and stronger expression was detected in WDSCC. https://knepublishing.com/index.php/SJMS/article/view/9953Cyclin D1oral squamous cell carcinoma (OSCC)ToombakSudanese oral cancerimmunohistochemistry |
| spellingShingle | Malak Abdulrahman Seid Ahmed Nazik Omer Ahmed M. Suliman Mona Ellaithi Expression of Cyclin D1 in Oral Squamous Cell Carcinoma Sudan Journal of Medical Sciences Cyclin D1 oral squamous cell carcinoma (OSCC) Toombak Sudanese oral cancer immunohistochemistry |
| title | Expression of Cyclin D1 in Oral Squamous Cell Carcinoma |
| title_full | Expression of Cyclin D1 in Oral Squamous Cell Carcinoma |
| title_fullStr | Expression of Cyclin D1 in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Expression of Cyclin D1 in Oral Squamous Cell Carcinoma |
| title_short | Expression of Cyclin D1 in Oral Squamous Cell Carcinoma |
| title_sort | expression of cyclin d1 in oral squamous cell carcinoma |
| topic | Cyclin D1 oral squamous cell carcinoma (OSCC) Toombak Sudanese oral cancer immunohistochemistry |
| url | https://knepublishing.com/index.php/SJMS/article/view/9953 |
| work_keys_str_mv | AT malakabdulrahmanseidahmed expressionofcyclind1inoralsquamouscellcarcinoma AT nazikomer expressionofcyclind1inoralsquamouscellcarcinoma AT ahmedmsuliman expressionofcyclind1inoralsquamouscellcarcinoma AT monaellaithi expressionofcyclind1inoralsquamouscellcarcinoma |