Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization
Abstract Background Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cel...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-025-04505-5 |
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| author | Peng-Chao Wang Jie Liu Yue-Fang Liu Yang Wu Lin-Li Xue Zhen-Shan Yang |
| author_facet | Peng-Chao Wang Jie Liu Yue-Fang Liu Yang Wu Lin-Li Xue Zhen-Shan Yang |
| author_sort | Peng-Chao Wang |
| collection | DOAJ |
| description | Abstract Background Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cells at the implantation site. COX2-specific inhibitor Valdecoxib and mPGES1 selective inhibitor MK886 were used to analyze the roles of mPGES1 and COX2 during mouse and human decidualization. During mouse in vitro decidualization, decidua/trophoblast prolactin-related protein (Dtprp) expression was significantly suppressed by Valdecoxib and MK886. Under human in vitro decidualization, mPGES1 significantly increases, while both cPGES and mPGES2 remain unchanged. PGE2-mediated upregulation of insulin growth factor binding protein 1 (IGFBP1) was significantly inhibited by Valdecoxib and MK886. Conclusions Our findings suggest the involvement of COX2/mPGES1/PGE2 pathway in both mouse and human decidualization. |
| format | Article |
| id | doaj-art-e85e2fe234c941fdbf98887855f408c2 |
| institution | Kabale University |
| issn | 1746-6148 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj-art-e85e2fe234c941fdbf98887855f408c22025-02-02T12:29:08ZengBMCBMC Veterinary Research1746-61482025-01-012111810.1186/s12917-025-04505-5Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualizationPeng-Chao Wang0Jie Liu1Yue-Fang Liu2Yang Wu3Lin-Li Xue4Zhen-Shan Yang5College of Veterinary Medicine, Shanxi Agricultural UniversityDakewe Biotech Co., Ltd.Department of Cell Biology, Zunyi Medical UniversityDepartment of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalDepartment of Basic Science, Shanxi Agricultural UniversityDivision of Oncology, Department of Clinical Sciences, Lund UniversityAbstract Background Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cells at the implantation site. COX2-specific inhibitor Valdecoxib and mPGES1 selective inhibitor MK886 were used to analyze the roles of mPGES1 and COX2 during mouse and human decidualization. During mouse in vitro decidualization, decidua/trophoblast prolactin-related protein (Dtprp) expression was significantly suppressed by Valdecoxib and MK886. Under human in vitro decidualization, mPGES1 significantly increases, while both cPGES and mPGES2 remain unchanged. PGE2-mediated upregulation of insulin growth factor binding protein 1 (IGFBP1) was significantly inhibited by Valdecoxib and MK886. Conclusions Our findings suggest the involvement of COX2/mPGES1/PGE2 pathway in both mouse and human decidualization.https://doi.org/10.1186/s12917-025-04505-5PGE2mPGES1COX2DecidualizationEndometrial stromal cell |
| spellingShingle | Peng-Chao Wang Jie Liu Yue-Fang Liu Yang Wu Lin-Li Xue Zhen-Shan Yang Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization BMC Veterinary Research PGE2 mPGES1 COX2 Decidualization Endometrial stromal cell |
| title | Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization |
| title_full | Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization |
| title_fullStr | Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization |
| title_full_unstemmed | Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization |
| title_short | Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization |
| title_sort | participation of cox2 mpges1 pge2 in mouse and human endometrial stromal decidualization |
| topic | PGE2 mPGES1 COX2 Decidualization Endometrial stromal cell |
| url | https://doi.org/10.1186/s12917-025-04505-5 |
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