Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy
Background. Few studies regarding chronic kidney disease (CKD) and anemia have been conducted in patients with Chagas cardiomyopathy (CC). We evaluated the risk prediction performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and anemia in CC patients. Methods. From...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/6417874 |
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| author | Marcelo Arruda Nakazone Maurício Nassau Machado Ana Paula Otaviano Ana Maria Silveira Rodrigues Augusto Cardinalli-Neto Reinaldo Bulgarelli Bestetti |
| author_facet | Marcelo Arruda Nakazone Maurício Nassau Machado Ana Paula Otaviano Ana Maria Silveira Rodrigues Augusto Cardinalli-Neto Reinaldo Bulgarelli Bestetti |
| author_sort | Marcelo Arruda Nakazone |
| collection | DOAJ |
| description | Background. Few studies regarding chronic kidney disease (CKD) and anemia have been conducted in patients with Chagas cardiomyopathy (CC). We evaluated the risk prediction performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and anemia in CC patients. Methods. From 2000 to 2010, a total of 232 patients were studied in a single-center retrospective study. CKD was defined as creatinine clearance <60 mL/min/1.73 m2 according to CKD-EPI equation. Anemia was defined as hemoglobin <12 g/dL (women) and <13 g/dL (men). Cox proportional hazards models were used to establish predictors for death. Results. At baseline, 98 individuals (42.2%) had criteria for CKD and 41 (17.7%) for anemia. During follow-up, 136 patients (58.6%) died. Independently, CKD and anemia were not associated with all-cause mortality. However, when they coexisted, an additional risk was attributed for these patients. Cox proportional hazard models analysis identified systolic blood pressure (hazard ratio, 0.99; 95% confidence interval (CI), 0.98 to 1.00; P=0.015), implantable cardioverter-defibrillator (hazard ratio, 0.48; 95% CI, 0.27 to 0.85; P=0.012), left anterior fascicular block (hazard ratio, 1.52; 95% CI, 1.08 to 2.13; P=0.017), left ventricular end-diastolic diameter (hazard ratio, 1.04; 95% CI, 1.02 to 1.06; P<0.001), and serum sodium (hazard ratio, 0.95; 95% CI, 0.92 to 0.99; P=0.020) as independent predictors for death. Conclusions. CKD and anemia are not independent predictors for long-term mortality in CC patients. However, the prognosis is poorer in individuals with both comorbidities. |
| format | Article |
| id | doaj-art-e8581d98f7204cebb74eb33f1b6522e0 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-e8581d98f7204cebb74eb33f1b6522e02025-02-03T06:46:56ZengWileyCardiology Research and Practice2090-80162090-05972020-01-01202010.1155/2020/64178746417874Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas CardiomyopathyMarcelo Arruda Nakazone0Maurício Nassau Machado1Ana Paula Otaviano2Ana Maria Silveira Rodrigues3Augusto Cardinalli-Neto4Reinaldo Bulgarelli Bestetti5Postgraduate Division, São José do Rio Preto Medical School, 5416 Brigadeiro Faria Lima Ave., CEP 15090-000, São José do Rio Preto, BrazilHospital de Base, Fundação Faculdade Regional de Medicina de São José do Rio Preto, 5544 Brigadeiro Faria Lima Ave., CEP 15090-000, São José do Rio Preto, BrazilHospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, Campus Universitário, Ribeirão Preto CEP 14048-900, BrazilSpecialized Nursing Department, São José do Rio Preto Medical School, 5416 Brigadeiro Faria Lima Ave., CEP 15090-000, São José do Rio Preto, BrazilHospital de Base, Fundação Faculdade Regional de Medicina de São José do Rio Preto, 5544 Brigadeiro Faria Lima Ave., CEP 15090-000, São José do Rio Preto, BrazilPostgraduate Division, São José do Rio Preto Medical School, 5416 Brigadeiro Faria Lima Ave., CEP 15090-000, São José do Rio Preto, BrazilBackground. Few studies regarding chronic kidney disease (CKD) and anemia have been conducted in patients with Chagas cardiomyopathy (CC). We evaluated the risk prediction performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and anemia in CC patients. Methods. From 2000 to 2010, a total of 232 patients were studied in a single-center retrospective study. CKD was defined as creatinine clearance <60 mL/min/1.73 m2 according to CKD-EPI equation. Anemia was defined as hemoglobin <12 g/dL (women) and <13 g/dL (men). Cox proportional hazards models were used to establish predictors for death. Results. At baseline, 98 individuals (42.2%) had criteria for CKD and 41 (17.7%) for anemia. During follow-up, 136 patients (58.6%) died. Independently, CKD and anemia were not associated with all-cause mortality. However, when they coexisted, an additional risk was attributed for these patients. Cox proportional hazard models analysis identified systolic blood pressure (hazard ratio, 0.99; 95% confidence interval (CI), 0.98 to 1.00; P=0.015), implantable cardioverter-defibrillator (hazard ratio, 0.48; 95% CI, 0.27 to 0.85; P=0.012), left anterior fascicular block (hazard ratio, 1.52; 95% CI, 1.08 to 2.13; P=0.017), left ventricular end-diastolic diameter (hazard ratio, 1.04; 95% CI, 1.02 to 1.06; P<0.001), and serum sodium (hazard ratio, 0.95; 95% CI, 0.92 to 0.99; P=0.020) as independent predictors for death. Conclusions. CKD and anemia are not independent predictors for long-term mortality in CC patients. However, the prognosis is poorer in individuals with both comorbidities.http://dx.doi.org/10.1155/2020/6417874 |
| spellingShingle | Marcelo Arruda Nakazone Maurício Nassau Machado Ana Paula Otaviano Ana Maria Silveira Rodrigues Augusto Cardinalli-Neto Reinaldo Bulgarelli Bestetti Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy Cardiology Research and Practice |
| title | Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy |
| title_full | Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy |
| title_fullStr | Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy |
| title_full_unstemmed | Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy |
| title_short | Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy |
| title_sort | prognostic significance of chronic kidney disease ckd epi equation and anemia in patients with chronic heart failure secondary to chagas cardiomyopathy |
| url | http://dx.doi.org/10.1155/2020/6417874 |
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