Sodium thiosulfate does not affect energy metabolism or organ (dys)function during resuscitation from murine trauma-and-hemorrhage

Sodium thiosulfate does not affect energy metabolism or organ (dys)function during resuscitation from murine trauma-and-hemorrhage

Abstract Background In murine models, controversial data have been reported on the effect of hydrogen sulfide (H2S) administration during resuscitation from trauma-and-hemorrhage. The H2S donor sodium thiosulfate (Na2S2O3) is a recognized drug devoid of major side effects, and, hence, we determined...

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Bibliographic Details
Main Authors: Maximilian Feth, Mirabel Gracco, Michael Gröger, Melanie Hogg, Sandra Kress, Andrea Hoffmann, Enrico Calzia, Ulrich Wachter, Peter Radermacher, Tamara Merz
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:Intensive Care Medicine Experimental
Subjects:
H2S
Oxidative stress
Nitrosative stress
Mitochondrial function
Stable isotopes
Metabolism
Online Access:https://doi.org/10.1186/s40635-025-00778-0
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