Establishment and Characterization of a Brain Parenchymal Metastatic Cell Line AlmoR1 Derived From an NSCLC Patient With EGFR‐TKI Resistance

Establishment and Characterization of a Brain Parenchymal Metastatic Cell Line AlmoR1 Derived From an NSCLC Patient With EGFR‐TKI Resistance

ABSTRACT Background Non‐small cell lung cancer patients with EGFR mutation have a high rate of brain metastases, and EGFR tyrosine kinase inhibitors (TKIs) are the principal therapeutic approach. However, acquired targeted therapy resistance is the main reason for EGFR‐TKIs' treatment failure....

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Bibliographic Details
Main Authors: Jingyi Wu, Xiangfei Wu, Jing Wang, Guili Feng, Yuhan Wang, Zide Chen, Wei Wang, Rong Wang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Cancer Medicine
Subjects:
AlmoR1
brain metastasis
NSCLC
primary culture
the resistance of third‐generation EGFR‐TKIs
Online Access:https://doi.org/10.1002/cam4.70827
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https://doi.org/10.1002/cam4.70827

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