Estrogen receptor α regulates SVCT2 protein level in human breast cancer cells

Estrogen receptor α regulates SVCT2 protein level in human breast cancer cells

Abstract The solute carrier (SLC) protein family, traditionally recognized for transporting molecules across cell membranes, is gaining attention for its broader roles, including signaling. Among SLC proteins, the ascorbate transporter SVCT2 remains poorly understood, particularly in relation to est...

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Bibliographic Details
Main Authors: Soon Young Jang, Eunbi Hong, Yebin Jo, Jiyun Kim, Jong-Ho Kim, Yuran Na, Chang-Hwan Yeom, Yoon Jung Yang, Emanuela Jacchetti, Manuela Teresa Raimondi, Seyeon Park
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SVCT2
Estrogen receptor alpha
Degradation
XIAP
Drug resistance
Breast cancer
Online Access:https://doi.org/10.1038/s41598-025-11758-5
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