Polyomavirus large T antigens: Unraveling a complex interactome
All members of the polyomavirus family encode a large T antigen (LT) protein that plays essential roles in viral DNA replication, regulation of viral gene expression, and the manipulation of numerous cellular pathways. Over 100 polyomaviruses have been discovered in hosts ranging from arthropods and...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Tumour Virus Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666679024000302 |
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| author | Matthew R. Googins Ping An Christian H. Gauthier James M. Pipas |
| author_facet | Matthew R. Googins Ping An Christian H. Gauthier James M. Pipas |
| author_sort | Matthew R. Googins |
| collection | DOAJ |
| description | All members of the polyomavirus family encode a large T antigen (LT) protein that plays essential roles in viral DNA replication, regulation of viral gene expression, and the manipulation of numerous cellular pathways. Over 100 polyomaviruses have been discovered in hosts ranging from arthropods and fish to mammals, including fourteen that infect humans. LT is among the most studied viral proteins with thousands of articles describing its functions in viral productive infection and tumorigenesis. However, nearly all knowledge of LT activities is based on the studies of simian virus 40 (SV40) and a few other viruses. Comparative studies of LT proteins of different polyomaviruses have revealed a remarkable diversity in the mechanisms by which LT proteins function across different polyomavirus species. This review focuses on human polyomaviruses highlights the similarities and differences between polyomavirus LTs and highlights gaps in our understanding of this protein family. The concentration of knowledge around SV40 LT and the corresponding lack of mechanistic studies on LT proteins encoded by other human and animal polyomaviruses severely constrains our understanding of the biology of this important virus family. |
| format | Article |
| id | doaj-art-e835c2f80e3c4ac69edcf77bbe0bc839 |
| institution | Kabale University |
| issn | 2666-6790 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tumour Virus Research |
| spelling | doaj-art-e835c2f80e3c4ac69edcf77bbe0bc8392025-08-20T03:45:28ZengElsevierTumour Virus Research2666-67902025-06-011920030610.1016/j.tvr.2024.200306Polyomavirus large T antigens: Unraveling a complex interactomeMatthew R. Googins0Ping An1Christian H. Gauthier2James M. Pipas3Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USADepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USADepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USACorresponding author.; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USAAll members of the polyomavirus family encode a large T antigen (LT) protein that plays essential roles in viral DNA replication, regulation of viral gene expression, and the manipulation of numerous cellular pathways. Over 100 polyomaviruses have been discovered in hosts ranging from arthropods and fish to mammals, including fourteen that infect humans. LT is among the most studied viral proteins with thousands of articles describing its functions in viral productive infection and tumorigenesis. However, nearly all knowledge of LT activities is based on the studies of simian virus 40 (SV40) and a few other viruses. Comparative studies of LT proteins of different polyomaviruses have revealed a remarkable diversity in the mechanisms by which LT proteins function across different polyomavirus species. This review focuses on human polyomaviruses highlights the similarities and differences between polyomavirus LTs and highlights gaps in our understanding of this protein family. The concentration of knowledge around SV40 LT and the corresponding lack of mechanistic studies on LT proteins encoded by other human and animal polyomaviruses severely constrains our understanding of the biology of this important virus family.http://www.sciencedirect.com/science/article/pii/S2666679024000302PolyomavirusesLarge T antigenProtein-protein interactionsPhosphorylationDNA replication |
| spellingShingle | Matthew R. Googins Ping An Christian H. Gauthier James M. Pipas Polyomavirus large T antigens: Unraveling a complex interactome Tumour Virus Research Polyomaviruses Large T antigen Protein-protein interactions Phosphorylation DNA replication |
| title | Polyomavirus large T antigens: Unraveling a complex interactome |
| title_full | Polyomavirus large T antigens: Unraveling a complex interactome |
| title_fullStr | Polyomavirus large T antigens: Unraveling a complex interactome |
| title_full_unstemmed | Polyomavirus large T antigens: Unraveling a complex interactome |
| title_short | Polyomavirus large T antigens: Unraveling a complex interactome |
| title_sort | polyomavirus large t antigens unraveling a complex interactome |
| topic | Polyomaviruses Large T antigen Protein-protein interactions Phosphorylation DNA replication |
| url | http://www.sciencedirect.com/science/article/pii/S2666679024000302 |
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