In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of Pseudoparticles
The 5′ untranslated region (5′ UTR) of rodent hepacivirus (RHV) and pegivirus (RPgV) contains sequence homology to the HCV type III internal ribosome entry sites (IRES). Utilizing a monocistronic expression vector with an RNA polymerase I promoter to drive transcription, we show cell-specific IRES t...
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Main Authors: | Stuart Sims, Kevin Michaelsen, Sara Burkhard, Cornel Fraefel |
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Format: | Article |
Language: | English |
Published: |
Wiley
2021-01-01
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Series: | Advances in Virology |
Online Access: | http://dx.doi.org/10.1155/2021/5569844 |
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