Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson’s disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta
Format:	Article
Language:	English
Published:	Wiley 2017-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2017/8302636
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate: Implications for Use as a Therapeutic for Parkinson’s Disease
by: Shankar J. Chinta, et al.
Published: (2012-01-01)

Potential Neuroprotective Effect of the Endocannabinoid System on Parkinson’s Disease
by: María Fernanda Urmeneta-Ortíz, et al.
Published: (2024-01-01)

The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease
by: Edward C. Lauterbach, et al.
Published: (2012-01-01)

Neuroprotective Transcription Factors in Animal Models of Parkinson Disease
by: François-Xavier Blaudin de Thé, et al.
Published: (2016-01-01)

Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease
by: Jason R. Richardson, et al.
Published: (2013-01-01)

Neuroprotective Effect of Taurine against Cell Death, Glial Changes, and Neuronal Loss in the Cerebellum of Rats Exposed to Chronic-Recurrent Neuroinflammation Induced by LPS
by: Samara P. Silva, et al.
Published: (2021-01-01)

Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease
by: Kelly Rose Tavares Neves, et al.
Published: (2015-01-01)

Glial Cells and the Neurobiology of Addiction
by: Diane M. P. Lawrence, et al.
Published: (2007-01-01)

RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection
by: Ignacio Silva-Llanes, et al.
Published: (2025-01-01)

Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease
by: Ewelina Palasz, et al.
Published: (2019-01-01)

Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease
by: Xiang-Yun Li, et al.
Published: (2015-01-01)

Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury
by: Mohammad Yassin Zamanian, et al.
Published: (2022-01-01)

The Role of Glial Cells in the Pathophysiology of Epilepsy
by: Filiz Onat, et al.
Published: (2025-01-01)

A Case of Nasal Glial Heterotopia in an Adult
by: Akira Hagiwara, et al.
Published: (2014-01-01)

Corrigendum to “Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons” [Brain Res. Bull. 154 (2020) 32–42]
by: Xiu-Qi Bao, et al.
Published: (2025-02-01)

Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells
by: Fraser I. Young, et al.
Published: (2016-01-01)

The role of glial cells in neuralgia: a bibliometric exploration
by: Ting He, et al.
Published: (2025-02-01)

Tight junction proteins in glial tumors development and progression
by: Jakub Moskal, et al.
Published: (2025-02-01)

Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease
by: Aracely Janneth Naranjo-Viteri, et al.
Published: (2025-03-01)

Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo
by: Chien-Wei Feng, et al.
Published: (2020-01-01)

Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis
by: Adam K. Walker, et al.
Published: (2011-01-01)

Neuroprotective Efficacy of <i>Astragalus mongholicus</i> in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms
by: Yongjae Hong, et al.
Published: (2025-01-01)

Value of EEG in the differentiation of glial tumor and encephalitis: a case report and review of literature
by: M. Jokubaitis, et al.
Published: (2020-12-01)

Neuroprotective Effect of Intrastriatal Caffeic Acid Phenethyl Ester Treatment in 6-OH Dopamine Model of Parkinson’s Disease in Rats
by: Burak Cem Soner, et al.
Published: (2021-01-01)

Differential Cannabinoid Receptor Expression during Reactive Gliosis: a Possible Implication for a Nonpsychotropic Neuroprotection
by: Daniele De Filippis, et al.
Published: (2009-01-01)

Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease
by: Wan-Ling Tsai, et al.
Published: (2019-01-01)

Differentiation of Human Embryonic Stem Cells into Neuron, Cholinergic, and Glial Cells
by: Kimia Hosseini, et al.
Published: (2020-01-01)

Regulation of Glial Cell Functions by PPAR-𝜸 Natural and Synthetic Agonists
by: Antonietta Bernardo, et al.
Published: (2008-01-01)

The Cannabinoids: An Overview. Therapeutic Implications in Vomiting and Nausea after Cancer Chemotherapy, in Appetite Promotion, in Multiple Sclerosis and in Neuroprotection
by: R Mechoulam, et al.
Published: (2001-01-01)

Neuroprotective effects of gastrodin in both in vivo and in vitro models of Parkinson's disease: Mechanisms from the perspective of oxidative stress, ferroptosis, and cellular senescence
by: Shanshan Li, et al.
Published: (2025-02-01)

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway
by: Wei Zhang, et al.
Published: (2016-01-01)

Area postrema syndrome in patients with autoimmune glial fibrillary acidic protein astrocytopathy
by: Qingchen Li, et al.
Published: (2025-01-01)

A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
by: Maria A. Gubbiotti, et al.
Published: (2025-01-01)

Glial cell line-derived neurotrophic factor in patients with age-related cataract
by: A.A. Shpak, et al.
Published: (2022-09-01)

Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease
by: Hugh Chan, et al.
Published: (2010-01-01)

An Insight of Vitamin E as Neuroprotective Agents
by: Hui-Min Yap, et al.
Published: (2020-04-01)

New Targets of Neuroprotection in Ischemic Stroke
by: Marco Bacigaluppi, et al.
Published: (2008-01-01)

Pisa Syndrome in Parkinson’s Disease: Electromyographic Aspects and Implications for Rehabilitation
by: Giuseppe Frazzitta, et al.
Published: (2015-01-01)

Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects
by: Zi-Han Xu, et al.
Published: (2025-01-01)

The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity
by: Kathryn M. Madalena, et al.
Published: (2017-01-01)