Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers

The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described. Subsequent studies on cell viability showed that these compounds are not cytotoxic. Binding to several DNA structures was studied by competitive dialysis,...

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Bibliographic Details
Main Authors: Rubén Ferreira, Anna Aviñó, Ricardo Pérez-Tomás, Raimundo Gargallo, Ramon Eritja
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.4061/2010/489060
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