Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review

Myeloid sarcoma (MS) is an extramedullary manifestation of acute myeloid leukemia (AML) and commonly occurs in sites such as the lymph nodes, skin, soft tissues, and bone. It more rarely manifests in the pancreas, with less than 20 cases reported in the literature since 1987. Despite its rarity, MS...

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Main Authors: Laura E. Lavette, Angela G. Niehaus, Clancy J. Clark, Jason D. Conway, Girish Mishra, Darius A. Jahann
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Case Reports in Gastrointestinal Medicine
Online Access:http://dx.doi.org/10.1155/2024/5513857
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author Laura E. Lavette
Angela G. Niehaus
Clancy J. Clark
Jason D. Conway
Girish Mishra
Darius A. Jahann
author_facet Laura E. Lavette
Angela G. Niehaus
Clancy J. Clark
Jason D. Conway
Girish Mishra
Darius A. Jahann
author_sort Laura E. Lavette
collection DOAJ
description Myeloid sarcoma (MS) is an extramedullary manifestation of acute myeloid leukemia (AML) and commonly occurs in sites such as the lymph nodes, skin, soft tissues, and bone. It more rarely manifests in the pancreas, with less than 20 cases reported in the literature since 1987. Despite its rarity, MS should be considered in the differential diagnosis of a soft tissue mass causing obstructive jaundice, especially if the patient has a known hematologic disease. Isolated cases of pancreatic MS have been known to progress to AML; therefore, it is crucial to differentiate MS from more common diagnoses, such as pancreatic cancer or pancreatitis. This is a case of a 70-year-old male with symptomatic obstructive jaundice secondary to pancreatic MS, ultimately requiring endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and management. Also included is a comprehensive review of previous case reports with similar clinical presentations, management, and treatment of pancreatic MS.
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spelling doaj-art-e814835c858342d39b70c536c5b62bfd2025-02-03T05:55:28ZengWileyCase Reports in Gastrointestinal Medicine2090-65362024-01-01202410.1155/2024/5513857Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature ReviewLaura E. Lavette0Angela G. Niehaus1Clancy J. Clark2Jason D. Conway3Girish Mishra4Darius A. Jahann5Department of Internal MedicineDepartment of PathologyDepartment of SurgeryDepartment of MedicineDepartment of MedicineDepartment of MedicineMyeloid sarcoma (MS) is an extramedullary manifestation of acute myeloid leukemia (AML) and commonly occurs in sites such as the lymph nodes, skin, soft tissues, and bone. It more rarely manifests in the pancreas, with less than 20 cases reported in the literature since 1987. Despite its rarity, MS should be considered in the differential diagnosis of a soft tissue mass causing obstructive jaundice, especially if the patient has a known hematologic disease. Isolated cases of pancreatic MS have been known to progress to AML; therefore, it is crucial to differentiate MS from more common diagnoses, such as pancreatic cancer or pancreatitis. This is a case of a 70-year-old male with symptomatic obstructive jaundice secondary to pancreatic MS, ultimately requiring endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and management. Also included is a comprehensive review of previous case reports with similar clinical presentations, management, and treatment of pancreatic MS.http://dx.doi.org/10.1155/2024/5513857
spellingShingle Laura E. Lavette
Angela G. Niehaus
Clancy J. Clark
Jason D. Conway
Girish Mishra
Darius A. Jahann
Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review
Case Reports in Gastrointestinal Medicine
title Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review
title_full Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review
title_fullStr Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review
title_full_unstemmed Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review
title_short Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review
title_sort pancreatic myeloid sarcoma causing obstructive jaundice a case report and literature review
url http://dx.doi.org/10.1155/2024/5513857
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