Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach
Miniaturized analytical chip devices like biosensors nowadays provide assistance in highly diverse fields of application such as point-of-care diagnostics and industrial bioprocess engineering. However, upon contact with fluids, the sensor requires a protective shell for its electrical components th...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2014/713603 |
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| author | Sebastian-Tim Schmitz-Hertzberg Rick Liese Carsten Terjung Frank F. Bier |
| author_facet | Sebastian-Tim Schmitz-Hertzberg Rick Liese Carsten Terjung Frank F. Bier |
| author_sort | Sebastian-Tim Schmitz-Hertzberg |
| collection | DOAJ |
| description | Miniaturized analytical chip devices like biosensors nowadays provide assistance in highly diverse fields of application such as point-of-care diagnostics and industrial bioprocess engineering. However, upon contact with fluids, the sensor requires a protective shell for its electrical components that simultaneously offers controlled access for the target analytes to the measuring units. We therefore developed a capsule that comprises a permeable and a sealed compartment consisting of variable polymers such as biocompatible and biodegradable polylactic acid (PLA) for medical applications or more economical polyvinyl chloride (PVC) and polystyrene (PS) polymers for bioengineering applications. Production of the sealed capsule compartments was performed by heat pressing of polymer pellets placed in individually designable molds. Controlled permeability of the opposite compartments was achieved by inclusion of NaCl inside the polymer matrix during heat pressing, followed by its subsequent release in aqueous solution. Correlating diffusion rates through the so made permeable capsule compartments were quantified for preselected model analytes: glucose, peroxidase, and polystyrene beads of three different diameters (1.4 μm, 4.2 μm, and 20.0 μm). In summary, the presented capsule system turned out to provide sufficient shelter for small-sized electronic devices and gives insight into its potential permeability for defined substances of analytical interest. |
| format | Article |
| id | doaj-art-e8105a916523441e96d0d78e3456d41d |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-e8105a916523441e96d0d78e3456d41d2025-02-03T06:41:59ZengWileyInternational Journal of Polymer Science1687-94221687-94302014-01-01201410.1155/2014/713603713603Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New ApproachSebastian-Tim Schmitz-Hertzberg0Rick Liese1Carsten Terjung2Frank F. Bier3Fraunhofer Institute for Biomedical Engineering IBMT, Branch Potsdam, Am Muehlenberg 13, 14476 Potsdam, GermanyFraunhofer Institute for Biomedical Engineering IBMT, Branch Potsdam, Am Muehlenberg 13, 14476 Potsdam, GermanyFraunhofer Institute for Biomedical Engineering IBMT, Branch Potsdam, Am Muehlenberg 13, 14476 Potsdam, GermanyFraunhofer Institute for Biomedical Engineering IBMT, Branch Potsdam, Am Muehlenberg 13, 14476 Potsdam, GermanyMiniaturized analytical chip devices like biosensors nowadays provide assistance in highly diverse fields of application such as point-of-care diagnostics and industrial bioprocess engineering. However, upon contact with fluids, the sensor requires a protective shell for its electrical components that simultaneously offers controlled access for the target analytes to the measuring units. We therefore developed a capsule that comprises a permeable and a sealed compartment consisting of variable polymers such as biocompatible and biodegradable polylactic acid (PLA) for medical applications or more economical polyvinyl chloride (PVC) and polystyrene (PS) polymers for bioengineering applications. Production of the sealed capsule compartments was performed by heat pressing of polymer pellets placed in individually designable molds. Controlled permeability of the opposite compartments was achieved by inclusion of NaCl inside the polymer matrix during heat pressing, followed by its subsequent release in aqueous solution. Correlating diffusion rates through the so made permeable capsule compartments were quantified for preselected model analytes: glucose, peroxidase, and polystyrene beads of three different diameters (1.4 μm, 4.2 μm, and 20.0 μm). In summary, the presented capsule system turned out to provide sufficient shelter for small-sized electronic devices and gives insight into its potential permeability for defined substances of analytical interest.http://dx.doi.org/10.1155/2014/713603 |
| spellingShingle | Sebastian-Tim Schmitz-Hertzberg Rick Liese Carsten Terjung Frank F. Bier Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach International Journal of Polymer Science |
| title | Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach |
| title_full | Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach |
| title_fullStr | Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach |
| title_full_unstemmed | Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach |
| title_short | Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach |
| title_sort | towards a smart encapsulation system for small sized electronic devices a new approach |
| url | http://dx.doi.org/10.1155/2014/713603 |
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