Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil)
Side effects of antimalarial drug can overlap with malaria symptoms. We evaluated 50 patients with vivax malaria in Mâncio Lima, Acre, treated with chloroquine and primaquine. Patients were evaluated for the presence of 21 symptoms before and after treatment and for reported side effects of these dr...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/346853 |
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| author | Cássio Braga e Braga Antonio Camargo Martins Athaid David Escalante Cayotopa Wagner Werner Klein Andreus Roberto Schlosser Aline Ferreira da Silva Mardelson Nery de Souza Breno Wilson Benevides Andrade José Alcântara Filgueira-Júnior Wagner de Jesus Pinto Mônica da Silva-Nunes |
| author_facet | Cássio Braga e Braga Antonio Camargo Martins Athaid David Escalante Cayotopa Wagner Werner Klein Andreus Roberto Schlosser Aline Ferreira da Silva Mardelson Nery de Souza Breno Wilson Benevides Andrade José Alcântara Filgueira-Júnior Wagner de Jesus Pinto Mônica da Silva-Nunes |
| author_sort | Cássio Braga e Braga |
| collection | DOAJ |
| description | Side effects of antimalarial drug can overlap with malaria symptoms. We evaluated 50 patients with vivax malaria in Mâncio Lima, Acre, treated with chloroquine and primaquine. Patients were evaluated for the presence of 21 symptoms before and after treatment and for reported side effects of these drugs after treatment was started. The most frequent symptoms before medication were headache, fever, chills, sweating, arthralgia, back pain, and weakness, which were present in between 40% and 76% of respondents. The treatment reduced the occurrence of these symptoms and reduced the lack of appetite, but gastrointestinal symptoms and choluria increased in frequency. There were no reports of pale stools before medication, but 12% reported the occurrence of this symptom after treatment started. Other symptoms such as blurred vision (54%), pruritus (22%), paresthesia (6%), insomnia (46%), and “stings” into the skin (22%) were reported after chloroquine was taken. The antimalarial drugs used to treat P. vivax malaria reduce much of the systemic and algic symptoms but cause mainly gastrointestinal side effects that may lead to lack of adherence to drug treatment. It is important to guide the patient for the appearance and the transience of such side effects in order to avoid abandoning treatment. |
| format | Article |
| id | doaj-art-e80b92a09d85416796ca8d261485f035 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-e80b92a09d85416796ca8d261485f0352025-02-03T06:12:32ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982015-01-01201510.1155/2015/346853346853Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil)Cássio Braga e Braga0Antonio Camargo Martins1Athaid David Escalante Cayotopa2Wagner Werner Klein3Andreus Roberto Schlosser4Aline Ferreira da Silva5Mardelson Nery de Souza6Breno Wilson Benevides Andrade7José Alcântara Filgueira-Júnior8Wagner de Jesus Pinto9Mônica da Silva-Nunes10Centro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilCentro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04, 69920-900 Rio Branco, AC, BrazilSide effects of antimalarial drug can overlap with malaria symptoms. We evaluated 50 patients with vivax malaria in Mâncio Lima, Acre, treated with chloroquine and primaquine. Patients were evaluated for the presence of 21 symptoms before and after treatment and for reported side effects of these drugs after treatment was started. The most frequent symptoms before medication were headache, fever, chills, sweating, arthralgia, back pain, and weakness, which were present in between 40% and 76% of respondents. The treatment reduced the occurrence of these symptoms and reduced the lack of appetite, but gastrointestinal symptoms and choluria increased in frequency. There were no reports of pale stools before medication, but 12% reported the occurrence of this symptom after treatment started. Other symptoms such as blurred vision (54%), pruritus (22%), paresthesia (6%), insomnia (46%), and “stings” into the skin (22%) were reported after chloroquine was taken. The antimalarial drugs used to treat P. vivax malaria reduce much of the systemic and algic symptoms but cause mainly gastrointestinal side effects that may lead to lack of adherence to drug treatment. It is important to guide the patient for the appearance and the transience of such side effects in order to avoid abandoning treatment.http://dx.doi.org/10.1155/2015/346853 |
| spellingShingle | Cássio Braga e Braga Antonio Camargo Martins Athaid David Escalante Cayotopa Wagner Werner Klein Andreus Roberto Schlosser Aline Ferreira da Silva Mardelson Nery de Souza Breno Wilson Benevides Andrade José Alcântara Filgueira-Júnior Wagner de Jesus Pinto Mônica da Silva-Nunes Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) Interdisciplinary Perspectives on Infectious Diseases |
| title | Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) |
| title_full | Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) |
| title_fullStr | Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) |
| title_full_unstemmed | Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) |
| title_short | Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) |
| title_sort | side effects of chloroquine and primaquine and symptom reduction in malaria endemic area mancio lima acre brazil |
| url | http://dx.doi.org/10.1155/2015/346853 |
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