The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status
BackgroundGiven the ease of access to ambient temperature, it may be a more practical guide than the UVB index. However, the association between gestational temperature and vitamin D level in newborns remains unclear. Our study aims to explore this association and the necessity of maternal vitamin D...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1541427/full |
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| author | Wanjun Yin Wanjun Yin Wanjun Yin Wanjun Yin Lei Zhang Lei Zhang Peng Zhu Peng Zhu |
| author_facet | Wanjun Yin Wanjun Yin Wanjun Yin Wanjun Yin Lei Zhang Lei Zhang Peng Zhu Peng Zhu |
| author_sort | Wanjun Yin |
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| description | BackgroundGiven the ease of access to ambient temperature, it may be a more practical guide than the UVB index. However, the association between gestational temperature and vitamin D level in newborns remains unclear. Our study aims to explore this association and the necessity of maternal vitamin D supplementation when ambient temperature is less than a specific value.MethodsBased on a birth cohort study, we measured cord blood concentrations of 25(OH)D in 1419 neonates from January to September 2008 in Hefei, a new first-tier city in China. The daily mean temperature of Hefei was obtained from the China Meteorological Data Sharing Service System. Individual information on sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes was collected prospectively.ResultsThe best-fit relationship was observed in the regression model using a quadratic function to describe the association between the ambient temperature of the eighth gestational month (29–32 gestational weeks) and cord blood 25(OH)D concentrations (R2 = 0.358, p < 0.001). Ambient temperatures of 10 and 24.5°C were linked to the cutoff of vitamin D inadequacy (<50 nmol/L) and deficiency (<30 nmol/L) in cord blood, respectively. For maternal exposure to an ambient temperature of ≥24.5°C in the eighth gestational month, vitamin D supplementation during pregnancy failed to significantly enhance neonatal vitamin D concentrations. In contrast, for maternal exposure to ambient temperature of <10°C, maternal vitamin D supplementation was significantly associated with elevated 25(OH)D concentrations in cord blood.ConclusionGestational ambient temperature may be an ideal predictor for infant vitamin D status screening. Maternal exposure to an ambient temperature of less than 10°C is a critical index in the eighth gestational month, which may determine the onset of vitamin D supplementation. |
| format | Article |
| id | doaj-art-e80b8cd31a88418bb113a031a410e7cf |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-e80b8cd31a88418bb113a031a410e7cf2025-01-28T05:10:53ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15414271541427The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D statusWanjun Yin0Wanjun Yin1Wanjun Yin2Wanjun Yin3Lei Zhang4Lei Zhang5Peng Zhu6Peng Zhu7Joint Research Center of Occupational Medicine and Health, Institute of Grand Health, Hefei Comprehensive National Science Center, Anhui University of Science and Technology, Hefei, ChinaSchool of Public Health, Anhui University of Science and Technology, Hefei, ChinaKey Laboratory of Industrial Dust Prevention and Control, Occupational Safety and Health, Ministry of Education, Anhui University of Science and Technology, Huainan, ChinaMOE Key Laboratory of Population Health Across Life Cycle, Hefei, ChinaMOE Key Laboratory of Population Health Across Life Cycle, Hefei, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, ChinaMOE Key Laboratory of Population Health Across Life Cycle, Hefei, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, ChinaBackgroundGiven the ease of access to ambient temperature, it may be a more practical guide than the UVB index. However, the association between gestational temperature and vitamin D level in newborns remains unclear. Our study aims to explore this association and the necessity of maternal vitamin D supplementation when ambient temperature is less than a specific value.MethodsBased on a birth cohort study, we measured cord blood concentrations of 25(OH)D in 1419 neonates from January to September 2008 in Hefei, a new first-tier city in China. The daily mean temperature of Hefei was obtained from the China Meteorological Data Sharing Service System. Individual information on sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes was collected prospectively.ResultsThe best-fit relationship was observed in the regression model using a quadratic function to describe the association between the ambient temperature of the eighth gestational month (29–32 gestational weeks) and cord blood 25(OH)D concentrations (R2 = 0.358, p < 0.001). Ambient temperatures of 10 and 24.5°C were linked to the cutoff of vitamin D inadequacy (<50 nmol/L) and deficiency (<30 nmol/L) in cord blood, respectively. For maternal exposure to an ambient temperature of ≥24.5°C in the eighth gestational month, vitamin D supplementation during pregnancy failed to significantly enhance neonatal vitamin D concentrations. In contrast, for maternal exposure to ambient temperature of <10°C, maternal vitamin D supplementation was significantly associated with elevated 25(OH)D concentrations in cord blood.ConclusionGestational ambient temperature may be an ideal predictor for infant vitamin D status screening. Maternal exposure to an ambient temperature of less than 10°C is a critical index in the eighth gestational month, which may determine the onset of vitamin D supplementation.https://www.frontiersin.org/articles/10.3389/fnut.2025.1541427/fullpregnant womenvitamin D supplementationvitamin Dambient temperatureneonate |
| spellingShingle | Wanjun Yin Wanjun Yin Wanjun Yin Wanjun Yin Lei Zhang Lei Zhang Peng Zhu Peng Zhu The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status Frontiers in Nutrition pregnant women vitamin D supplementation vitamin D ambient temperature neonate |
| title | The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status |
| title_full | The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status |
| title_fullStr | The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status |
| title_full_unstemmed | The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status |
| title_short | The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status |
| title_sort | necessity of gestational vitamin d supplementation depends on ambient temperature concern for infant vitamin d status |
| topic | pregnant women vitamin D supplementation vitamin D ambient temperature neonate |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1541427/full |
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