Digital PCR-based quantification of miR-181a in the cerebrospinal fluid aids patient stratification in pediatric acute lymphoblastic leukemia

Digital PCR-based quantification of miR-181a in the cerebrospinal fluid aids patient stratification in pediatric acute lymphoblastic leukemia

Abstract Despite remarkable improvements in the survival of pediatric acute lymphoblastic leukemia (ALL), sensitive detection and clinical management of central nervous system leukemia (CNSL) are still immensely challenging. Blast cells residing in the CNS but not circulating in the cerebrospinal fl...

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Main Authors: Borbála Péterffy, Tamás J. Nádasi, Szilvia Krizsán, Anna Horváth, Ágnes Márk, Gábor Barna, Botond Timár, Laura Almási, Judit Müller, Krisztina Csanádi, Anna Rakonczai, Zsolt Nagy, Krisztián Kállay, Gabriella Kertész, Gergely Kriván, Monika Csóka, Anna Sebestyén, Ágnes F. Semsei, Gábor T. Kovács, Dániel J. Erdélyi, Csaba Bödör, Bálint Egyed, Donát Alpár
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Childhood acute lymphoblastic leukemia
Cerebrospinal fluid
Diagnostics
MicroRNA
Molecular genetics
Online Access:https://doi.org/10.1038/s41598-024-79733-0
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