Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries
Aim and Background. Early childhood caries (ECC) is a common type of dental caries affecting children. As dental caries is a bacterial infectious disease, the host immune system parameters including soluble human leukocyte antigen-G (sHLA-G) are essential factors in estimating dental caries. The stu...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2020/8870055 |
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| author | Mansoureh Bijani Amrollah Mostafazadeh Mina Motallebnejad Ali Bijani Roghiyeh Pourbagher Samaneh Gharekhani |
| author_facet | Mansoureh Bijani Amrollah Mostafazadeh Mina Motallebnejad Ali Bijani Roghiyeh Pourbagher Samaneh Gharekhani |
| author_sort | Mansoureh Bijani |
| collection | DOAJ |
| description | Aim and Background. Early childhood caries (ECC) is a common type of dental caries affecting children. As dental caries is a bacterial infectious disease, the host immune system parameters including soluble human leukocyte antigen-G (sHLA-G) are essential factors in estimating dental caries. The study aimed to investigate and compare the concentration of sHLA-G in the saliva of children with or without dental caries. Methods and Materials. This analytic cross-sectional study was carried out on 83 healthy children aged 3 to 5 years of both genders, who were divided into three groups based on decayed dental surfaces (ds): group 1, caries-free children (CF, n = 29); group 2, children with 1 ≤ ds ≤ 3, 1 ≤ ds ≤ 4, and 1 ≤ ds ≤ 5 for age 3, 4, and 5 years, respectively (ECC, n = 20); and group 3, children with ds ≥ 4, ds ≥ 5, and ds ≥ 6 for age 3, 4, and 5 years, respectively (S-ECC, n = 34). The unstimulated saliva samples were collected, and the salivary sHLA-G concentration was measured by the ELISA kit. The SPSS Statistics v17.0 software and Mann–Whitney, Kruskal–Wallis, chi-square, and Spearman’s rank correlation tests were used for statistical analysis. The level of significance was considered at p<0.05. Results. The mean concentrations of salivary sHLA-G in CF, ECC, and S-ECC groups were 3.18 ± 2.28, 5.64 ± 5.51, and 6.21 ± 6.03 ng/l, respectively (p=0.047), and the mean salivary sHLA-G level was comparatively higher in children with dental caries than that of the CF group (p=0.02), but there is no significant difference between ECC and S-ECC groups (p>0.05). Spearman’s rank correlation test showed a weak positive correlation (p=0.039, r = 0.22), between the level of salivary sHLA-G and dental caries. Conclusion. The present study provides some preliminary evidences on relationship between sHLA-G and dental caries in children. |
| format | Article |
| id | doaj-art-e809a9df6de942a3a95e1bf34fd195bc |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-e809a9df6de942a3a95e1bf34fd195bc2025-02-03T01:04:07ZengWileyInternational Journal of Dentistry1687-87281687-87362020-01-01202010.1155/2020/88700558870055Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental CariesMansoureh Bijani0Amrollah Mostafazadeh1Mina Motallebnejad2Ali Bijani3Roghiyeh Pourbagher4Samaneh Gharekhani5Student Research Committee, Babol University of Medical Science, Babol, IranCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Science, Babol, IranOral Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, IranSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, IranCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Science, Babol, IranOral Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, IranAim and Background. Early childhood caries (ECC) is a common type of dental caries affecting children. As dental caries is a bacterial infectious disease, the host immune system parameters including soluble human leukocyte antigen-G (sHLA-G) are essential factors in estimating dental caries. The study aimed to investigate and compare the concentration of sHLA-G in the saliva of children with or without dental caries. Methods and Materials. This analytic cross-sectional study was carried out on 83 healthy children aged 3 to 5 years of both genders, who were divided into three groups based on decayed dental surfaces (ds): group 1, caries-free children (CF, n = 29); group 2, children with 1 ≤ ds ≤ 3, 1 ≤ ds ≤ 4, and 1 ≤ ds ≤ 5 for age 3, 4, and 5 years, respectively (ECC, n = 20); and group 3, children with ds ≥ 4, ds ≥ 5, and ds ≥ 6 for age 3, 4, and 5 years, respectively (S-ECC, n = 34). The unstimulated saliva samples were collected, and the salivary sHLA-G concentration was measured by the ELISA kit. The SPSS Statistics v17.0 software and Mann–Whitney, Kruskal–Wallis, chi-square, and Spearman’s rank correlation tests were used for statistical analysis. The level of significance was considered at p<0.05. Results. The mean concentrations of salivary sHLA-G in CF, ECC, and S-ECC groups were 3.18 ± 2.28, 5.64 ± 5.51, and 6.21 ± 6.03 ng/l, respectively (p=0.047), and the mean salivary sHLA-G level was comparatively higher in children with dental caries than that of the CF group (p=0.02), but there is no significant difference between ECC and S-ECC groups (p>0.05). Spearman’s rank correlation test showed a weak positive correlation (p=0.039, r = 0.22), between the level of salivary sHLA-G and dental caries. Conclusion. The present study provides some preliminary evidences on relationship between sHLA-G and dental caries in children.http://dx.doi.org/10.1155/2020/8870055 |
| spellingShingle | Mansoureh Bijani Amrollah Mostafazadeh Mina Motallebnejad Ali Bijani Roghiyeh Pourbagher Samaneh Gharekhani Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries International Journal of Dentistry |
| title | Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries |
| title_full | Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries |
| title_fullStr | Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries |
| title_full_unstemmed | Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries |
| title_short | Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries |
| title_sort | evaluation of the level of salivary shla g in children aged 3 5 years with or without dental caries |
| url | http://dx.doi.org/10.1155/2020/8870055 |
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