Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis
Background Interleukin (IL)-41 is a novel cytokine, also known as Metrnl, and its role in ankylosing spondylitis (AS) remains unknown. The aim of this study is to measure the serum IL-41 levels in AS patients and their correlation with other clinical indicators.Methods This study recruited 106 parti...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2025.2545732 |
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| author | Wubing Lu Zhi Li Shanjun Shi Sicen Meng Jieru Pang Yan Li Mingcai Li |
| author_facet | Wubing Lu Zhi Li Shanjun Shi Sicen Meng Jieru Pang Yan Li Mingcai Li |
| author_sort | Wubing Lu |
| collection | DOAJ |
| description | Background Interleukin (IL)-41 is a novel cytokine, also known as Metrnl, and its role in ankylosing spondylitis (AS) remains unknown. The aim of this study is to measure the serum IL-41 levels in AS patients and their correlation with other clinical indicators.Methods This study recruited 106 participants, including 32 active AS patients, 32 inactive AS patients, and 42 healthy controls (HC). Basic information and clinical indicators of participants were obtained through physical examination and blood sample testing. Enzyme-linked immunosorbent assay was used to detect IL-41 levels.Results Patients with active and inactive AS had significantly higher serum IL-41 levels than HC. Moreover, correlation analysis showed that IL-41 in active AS was positively correlated with lymphocyte percentage; IL-41 in inactivated AS is negatively correlated with alkaline phosphatase and creatinine. IL-41 as an independent protective factor for AS had good value for the diagnosis of AS.Conclusion This study indicates that serum IL-41 levels are elevated in both active and inactive AS patients, suggesting that IL-41 may be a novel biomarker for AS. |
| format | Article |
| id | doaj-art-e7f8afbae2944b78af8668d2e6bfa024 |
| institution | Kabale University |
| issn | 2056-5623 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-e7f8afbae2944b78af8668d2e6bfa0242025-08-20T03:47:13ZengTaylor & Francis GroupFuture Science OA2056-56232025-12-0111110.1080/20565623.2025.2545732Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitisWubing Lu0Zhi Li1Shanjun Shi2Sicen Meng3Jieru Pang4Yan Li5Mingcai Li6Department of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, ChinaDepartment of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, ChinaDepartment of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, ChinaDepartment of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, ChinaDepartment of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, ChinaDepartment of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, ChinaDepartment of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, ChinaBackground Interleukin (IL)-41 is a novel cytokine, also known as Metrnl, and its role in ankylosing spondylitis (AS) remains unknown. The aim of this study is to measure the serum IL-41 levels in AS patients and their correlation with other clinical indicators.Methods This study recruited 106 participants, including 32 active AS patients, 32 inactive AS patients, and 42 healthy controls (HC). Basic information and clinical indicators of participants were obtained through physical examination and blood sample testing. Enzyme-linked immunosorbent assay was used to detect IL-41 levels.Results Patients with active and inactive AS had significantly higher serum IL-41 levels than HC. Moreover, correlation analysis showed that IL-41 in active AS was positively correlated with lymphocyte percentage; IL-41 in inactivated AS is negatively correlated with alkaline phosphatase and creatinine. IL-41 as an independent protective factor for AS had good value for the diagnosis of AS.Conclusion This study indicates that serum IL-41 levels are elevated in both active and inactive AS patients, suggesting that IL-41 may be a novel biomarker for AS.https://www.tandfonline.com/doi/10.1080/20565623.2025.2545732Ankylosing spondylitisinterleukin-41Metrnldiagnostic markerlymphocyte percentagealkaline phosphatase |
| spellingShingle | Wubing Lu Zhi Li Shanjun Shi Sicen Meng Jieru Pang Yan Li Mingcai Li Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis Future Science OA Ankylosing spondylitis interleukin-41 Metrnl diagnostic marker lymphocyte percentage alkaline phosphatase |
| title | Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis |
| title_full | Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis |
| title_fullStr | Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis |
| title_full_unstemmed | Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis |
| title_short | Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis |
| title_sort | elevated serum interleukin 41 levels as a potential biomarker in ankylosing spondylitis |
| topic | Ankylosing spondylitis interleukin-41 Metrnl diagnostic marker lymphocyte percentage alkaline phosphatase |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2025.2545732 |
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