Compatibility Study of Lamivudine with Various Cellulose Polymers
For the development of any formulation, techniques such as thermal and isothermal stress testing were used to assess the compatibility of drug with excepients. Differential scanning calorimetry (DSC) and FTIR were the common methods for the study of compatibility. Isothermal stress testing (IST) is...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/726530 |
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| author | P. Narayana Raju K. Prakash M. Lakshmi Narasu |
| author_facet | P. Narayana Raju K. Prakash M. Lakshmi Narasu |
| author_sort | P. Narayana Raju |
| collection | DOAJ |
| description | For the development of any formulation, techniques such as thermal and isothermal stress testing were used to assess the compatibility of drug with excepients. Differential scanning calorimetry (DSC) and FTIR were the common methods for the study of compatibility. Isothermal stress testing (IST) is also a method for the compatibility study during proto type formulation. In the present study drug excepient compatibility study of lamivudine was conducted with different controlled release polymers. The drug and polymer mixtures were stored at 50 °C for 2 weeks. The samples were then characterized using DSC, FTIR and UV spectrophotometric methods. The results show that lamivudine was compatible with the all the polymers used in the study. The polymers used in the present study were definitely incorporated in the extended release lamivudine formulation. |
| format | Article |
| id | doaj-art-e7f41ec42e7b4e88ab86fd12ff8e34ce |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-e7f41ec42e7b4e88ab86fd12ff8e34ce2025-08-20T02:22:15ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016S1S17S2010.1155/2009/726530Compatibility Study of Lamivudine with Various Cellulose PolymersP. Narayana Raju0K. Prakash1M. Lakshmi Narasu2KLR College of Pharmacy, Paloncha, Khamman Dist., Andhrpradesh, IndiaFaculty of Pharmacy, 7th April University, Zawia, LibyaCentre for Biotechnology, Institute of Science and Technology, JNTU, Kukatpally, Hyderabad, Andhra Pradesh, IndiaFor the development of any formulation, techniques such as thermal and isothermal stress testing were used to assess the compatibility of drug with excepients. Differential scanning calorimetry (DSC) and FTIR were the common methods for the study of compatibility. Isothermal stress testing (IST) is also a method for the compatibility study during proto type formulation. In the present study drug excepient compatibility study of lamivudine was conducted with different controlled release polymers. The drug and polymer mixtures were stored at 50 °C for 2 weeks. The samples were then characterized using DSC, FTIR and UV spectrophotometric methods. The results show that lamivudine was compatible with the all the polymers used in the study. The polymers used in the present study were definitely incorporated in the extended release lamivudine formulation.http://dx.doi.org/10.1155/2009/726530 |
| spellingShingle | P. Narayana Raju K. Prakash M. Lakshmi Narasu Compatibility Study of Lamivudine with Various Cellulose Polymers E-Journal of Chemistry |
| title | Compatibility Study of Lamivudine with Various Cellulose Polymers |
| title_full | Compatibility Study of Lamivudine with Various Cellulose Polymers |
| title_fullStr | Compatibility Study of Lamivudine with Various Cellulose Polymers |
| title_full_unstemmed | Compatibility Study of Lamivudine with Various Cellulose Polymers |
| title_short | Compatibility Study of Lamivudine with Various Cellulose Polymers |
| title_sort | compatibility study of lamivudine with various cellulose polymers |
| url | http://dx.doi.org/10.1155/2009/726530 |
| work_keys_str_mv | AT pnarayanaraju compatibilitystudyoflamivudinewithvariouscellulosepolymers AT kprakash compatibilitystudyoflamivudinewithvariouscellulosepolymers AT mlakshminarasu compatibilitystudyoflamivudinewithvariouscellulosepolymers |