Natural compounds from ethno-medicinal plants exhibit multiple binding activities on SARS-CoV-2 spike protein receptor-binding domains

Natural compounds from ethno-medicinal plants exhibit multiple binding activities on SARS-CoV-2 spike protein receptor-binding domains

BackgroundCOVID-19, caused by SARS-CoV-2, is a communicable respiratory viral disease with no effective curative medicine. The structure of SARS-CoV-2 spike protein has conserved modules that facilitate both infection and fusion into human host cells. These modules serve as crucial targets for synth...

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Bibliographic Details
Main Authors: Trizah K. Milugo, Bethwell Owuor, Patrick W. Okanya, Kennedy Chepukosi, George F. Obiero
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Natural Products
Subjects:
antiviral activity
molecular modeling
spike-protein
human ACE-2
COVID-19
medicinal plants
Online Access:https://www.frontiersin.org/articles/10.3389/fntpr.2025.1597609/full
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