Mast cells: key players in digestive system tumors and their interactions with immune cells
Abstract Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune diseases. Recent studies in tumor-relat...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-024-02258-y |
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| author | Feihong Shu Jie Yu Youjia Liu Fang Wang Guoyou Gou Min Wen Chen Luo Xianmin Lu Yanxia Hu Qian Du Jingyu Xu Rui Xie |
| author_facet | Feihong Shu Jie Yu Youjia Liu Fang Wang Guoyou Gou Min Wen Chen Luo Xianmin Lu Yanxia Hu Qian Du Jingyu Xu Rui Xie |
| author_sort | Feihong Shu |
| collection | DOAJ |
| description | Abstract Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune diseases. Recent studies in tumor-related research have demonstrated that mast cells exert a substantial influence on tumor cell behavior and the tumor microenvironment, exhibiting both pro- and anti-tumor effects. Specifically, mast cells not only secrete mediators related to pro-tumor function such as trypsin-like enzymes, chymotrypsin, vascular endothelial cell growth factor and histamine, but also mediators related to anti-tumor progression such as cystatin C and IL-17F. This dual role of mast cells renders them an under-recognized but very promising target for tumor immunotherapy. Digestive system tumors, characterized by high morbidity and associated mortality rates globally, are increasingly recognized as a significant healthcare burden. This paper examines the influence of mast cell-derived mediators on the development of tumors in the digestive system. It also explores the prognostic significance of mast cells in patients with various gastrointestinal cancers at different stages of the disease. Additionally, the article investigates the interactions between mast cells and immune cells, as well as the potential relationships among intratumoral bacteria, immune cells, and mast cell within digestive system microenvironment. The aim is to propose new strategies for the immunotherapy of digestive system tumors by targeting mast cells. |
| format | Article |
| id | doaj-art-e7ed5901d5264256b7a51adb7bb13432 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-e7ed5901d5264256b7a51adb7bb134322025-01-19T12:10:31ZengNature Publishing GroupCell Death Discovery2058-77162025-01-0111111210.1038/s41420-024-02258-yMast cells: key players in digestive system tumors and their interactions with immune cellsFeihong Shu0Jie Yu1Youjia Liu2Fang Wang3Guoyou Gou4Min Wen5Chen Luo6Xianmin Lu7Yanxia Hu8Qian Du9Jingyu Xu10Rui Xie11Department of Endoscopy and Digestive System, Guizhou Provincial People’s HospitalDepartment of Endoscopy and Digestive System, Guizhou Provincial People’s HospitalZunyi Medical UniversityZunyi Medical UniversityZunyi Medical UniversityZunyi Medical UniversityZunyi Medical UniversityZunyi Medical UniversityZunyi Medical UniversityDepartment of Endoscopy and Digestive System, Guizhou Provincial People’s HospitalGuizhou Medical UniversityDepartment of Endoscopy and Digestive System, Guizhou Provincial People’s HospitalAbstract Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune diseases. Recent studies in tumor-related research have demonstrated that mast cells exert a substantial influence on tumor cell behavior and the tumor microenvironment, exhibiting both pro- and anti-tumor effects. Specifically, mast cells not only secrete mediators related to pro-tumor function such as trypsin-like enzymes, chymotrypsin, vascular endothelial cell growth factor and histamine, but also mediators related to anti-tumor progression such as cystatin C and IL-17F. This dual role of mast cells renders them an under-recognized but very promising target for tumor immunotherapy. Digestive system tumors, characterized by high morbidity and associated mortality rates globally, are increasingly recognized as a significant healthcare burden. This paper examines the influence of mast cell-derived mediators on the development of tumors in the digestive system. It also explores the prognostic significance of mast cells in patients with various gastrointestinal cancers at different stages of the disease. Additionally, the article investigates the interactions between mast cells and immune cells, as well as the potential relationships among intratumoral bacteria, immune cells, and mast cell within digestive system microenvironment. The aim is to propose new strategies for the immunotherapy of digestive system tumors by targeting mast cells.https://doi.org/10.1038/s41420-024-02258-y |
| spellingShingle | Feihong Shu Jie Yu Youjia Liu Fang Wang Guoyou Gou Min Wen Chen Luo Xianmin Lu Yanxia Hu Qian Du Jingyu Xu Rui Xie Mast cells: key players in digestive system tumors and their interactions with immune cells Cell Death Discovery |
| title | Mast cells: key players in digestive system tumors and their interactions with immune cells |
| title_full | Mast cells: key players in digestive system tumors and their interactions with immune cells |
| title_fullStr | Mast cells: key players in digestive system tumors and their interactions with immune cells |
| title_full_unstemmed | Mast cells: key players in digestive system tumors and their interactions with immune cells |
| title_short | Mast cells: key players in digestive system tumors and their interactions with immune cells |
| title_sort | mast cells key players in digestive system tumors and their interactions with immune cells |
| url | https://doi.org/10.1038/s41420-024-02258-y |
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