Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 Klebsiella pneumoniae during prolonged hospitalization of a single patient

Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 Klebsiella pneumoniae during prolonged hospitalization of a single patient

IntroductionCarbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global public health challenge due to its significant association with morbidity and mortality. Ceftazidime-avibactam (CZA) has emerged as an effective therapy against CRKP producing the serine carbapenemase KPC; how...

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Bibliographic Details
Main Authors: Shijun Sun, Chaoe Zhou, Haijun Li, Liying Sun, Saiqi Qi, Xinmin Liu, Wanhai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
KPC variants
carbapenem resistance
ceftazidime-avibactam resistance
Klebsiella pneumonia
antimicrobial susceptibility
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1543470/full
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