Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient
Hemophagocytic lymphohistiocytosis is a serious and potentially fatal disorder characterized by excessive immune system activation. The disorder is diagnosed mainly based on laboratory, clinical, and pathologic criteria. The spectrum comprises hereditary or “primary” HLH that comprises genetically h...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8833196 |
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| _version_ | 1832560216487493632 |
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| author | Ralph Kamel Rubal Sharma Divya Asti Arshpal Gill Yevgeniy Skaradinskiy |
| author_facet | Ralph Kamel Rubal Sharma Divya Asti Arshpal Gill Yevgeniy Skaradinskiy |
| author_sort | Ralph Kamel |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis is a serious and potentially fatal disorder characterized by excessive immune system activation. The disorder is diagnosed mainly based on laboratory, clinical, and pathologic criteria. The spectrum comprises hereditary or “primary” HLH that comprises genetically heterogeneous conditions, occurring during childhood. The secondary form presents later in life and is associated with several conditions mainly malignancy, autoimmune diseases, viral or bacterial infections, and hematological diseases. We present the case of an 80-year-old female patient who initially presented with an acute viral syndrome secondary to respiratory syncytial virus. The hospital course was complicated by disseminated intravascular coagulation and shock with multiorgan failure. Extensive workup revealed that several of the criteria for hemophagocytic lymphohistiocytosis were met. A review of literature fails to identify cases of hemophagocytic lymphohistiocytosis associated with respiratory syncytial virus in immunocompetent adults. This case report provides further insight on RSV as a possible etiologic agent associated with HLH and the importance of early recognition of this fatal disorder in RSV-positive patients who show unpredictable clinical decompensation. |
| format | Article |
| id | doaj-art-e7defa0449a549709d900ca3455cc632 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-e7defa0449a549709d900ca3455cc6322025-02-03T01:28:09ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/88331968833196Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly PatientRalph Kamel0Rubal Sharma1Divya Asti2Arshpal Gill3Yevgeniy Skaradinskiy4Staten Island University Hospital, Northwell Health, 475 Seaview Avenue, Staten Island, New York 10305, NY, USAStaten Island University Hospital, Northwell Health, 475 Seaview Avenue, Staten Island, New York 10305, NY, USAStaten Island University Hospital, Northwell Health, 475 Seaview Avenue, Staten Island, New York 10305, NY, USAStaten Island University Hospital, Northwell Health, 475 Seaview Avenue, Staten Island, New York 10305, NY, USAStaten Island University Hospital, Northwell Health, 475 Seaview Avenue, Staten Island, New York 10305, NY, USAHemophagocytic lymphohistiocytosis is a serious and potentially fatal disorder characterized by excessive immune system activation. The disorder is diagnosed mainly based on laboratory, clinical, and pathologic criteria. The spectrum comprises hereditary or “primary” HLH that comprises genetically heterogeneous conditions, occurring during childhood. The secondary form presents later in life and is associated with several conditions mainly malignancy, autoimmune diseases, viral or bacterial infections, and hematological diseases. We present the case of an 80-year-old female patient who initially presented with an acute viral syndrome secondary to respiratory syncytial virus. The hospital course was complicated by disseminated intravascular coagulation and shock with multiorgan failure. Extensive workup revealed that several of the criteria for hemophagocytic lymphohistiocytosis were met. A review of literature fails to identify cases of hemophagocytic lymphohistiocytosis associated with respiratory syncytial virus in immunocompetent adults. This case report provides further insight on RSV as a possible etiologic agent associated with HLH and the importance of early recognition of this fatal disorder in RSV-positive patients who show unpredictable clinical decompensation.http://dx.doi.org/10.1155/2020/8833196 |
| spellingShingle | Ralph Kamel Rubal Sharma Divya Asti Arshpal Gill Yevgeniy Skaradinskiy Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient Case Reports in Hematology |
| title | Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient |
| title_full | Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient |
| title_fullStr | Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient |
| title_full_unstemmed | Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient |
| title_short | Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient |
| title_sort | hemophagocytic lymphohistiocytosis associated with respiratory syncytial virus infection in an immunocompetent elderly patient |
| url | http://dx.doi.org/10.1155/2020/8833196 |
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