A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central India
Background: Several sporadic cases and outbreaks of Zika virus disease have been reported from different states of India. Objectives: This paper explored the possibility of any ongoing transmission of Zika virus (ZIKV) in the Bhopal region of Central India, where the last outbreak of this disease wa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Public Health |
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| Online Access: | https://journals.lww.com/10.4103/ijph.ijph_1098_23 |
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| author | Shashwati Nema Dipesh Kale Romesh Jain Ajay Halder Manisha Shrivastava Deepak Vaishnav Ashvini Kumar Yadav Divya Namdeo Debasis Biswas |
| author_facet | Shashwati Nema Dipesh Kale Romesh Jain Ajay Halder Manisha Shrivastava Deepak Vaishnav Ashvini Kumar Yadav Divya Namdeo Debasis Biswas |
| author_sort | Shashwati Nema |
| collection | DOAJ |
| description | Background:
Several sporadic cases and outbreaks of Zika virus disease have been reported from different states of India.
Objectives:
This paper explored the possibility of any ongoing transmission of Zika virus (ZIKV) in the Bhopal region of Central India, where the last outbreak of this disease was reported in 2018.
Materials and Methods:
We screened a group of 75 febrile patients who had already tested negative for the locally endemic causes of fever like dengue, chikungunya, enteric fever, malaria, and scrub typhus and two groups of asymptomatic healthy individuals represented by blood donors (n = 75) and antenatal mothers (n = 75). We tested blood samples of febrile patients for ZIKV RNA using real-time polymerase chain reaction (PCR), and for the healthy individuals, we determined anti-zika immunoglobulin G (IgG) antibodies using enzyme-linked immunosorbent assay.
Results:
ZIKV RNA was not detected in any of the 75 samples tested by real-time PCR assay. Among the voluntary blood donors and antenatal mothers, a total of 10 (15.38%) and 5 (6.66%) individuals were found to be seropositive for anti-ZIKV IgG antibodies, respectively. The seropositive group was found to have higher age 33.06 (±10.83) years as compared to seronegative individuals 26.60 (±5.12) years (P = 0.037).
Conclusion:
This study, which is the first survey of seroprevalence of anti-Zika antibodies from India, reports an overall seropositivity rate of 10% for anti-Zika antibodies among the healthy population, suggesting an ongoing, low level, silent transmission of ZIKV in the local community. |
| format | Article |
| id | doaj-art-e7db5f5de8dc48aaac4346ec423b4f92 |
| institution | Kabale University |
| issn | 0019-557X 2229-7693 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Public Health |
| spelling | doaj-art-e7db5f5de8dc48aaac4346ec423b4f922025-01-25T05:15:13ZengWolters Kluwer Medknow PublicationsIndian Journal of Public Health0019-557X2229-76932024-04-0168216316610.4103/ijph.ijph_1098_23A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central IndiaShashwati NemaDipesh KaleRomesh JainAjay HalderManisha ShrivastavaDeepak VaishnavAshvini Kumar YadavDivya NamdeoDebasis BiswasBackground: Several sporadic cases and outbreaks of Zika virus disease have been reported from different states of India. Objectives: This paper explored the possibility of any ongoing transmission of Zika virus (ZIKV) in the Bhopal region of Central India, where the last outbreak of this disease was reported in 2018. Materials and Methods: We screened a group of 75 febrile patients who had already tested negative for the locally endemic causes of fever like dengue, chikungunya, enteric fever, malaria, and scrub typhus and two groups of asymptomatic healthy individuals represented by blood donors (n = 75) and antenatal mothers (n = 75). We tested blood samples of febrile patients for ZIKV RNA using real-time polymerase chain reaction (PCR), and for the healthy individuals, we determined anti-zika immunoglobulin G (IgG) antibodies using enzyme-linked immunosorbent assay. Results: ZIKV RNA was not detected in any of the 75 samples tested by real-time PCR assay. Among the voluntary blood donors and antenatal mothers, a total of 10 (15.38%) and 5 (6.66%) individuals were found to be seropositive for anti-ZIKV IgG antibodies, respectively. The seropositive group was found to have higher age 33.06 (±10.83) years as compared to seronegative individuals 26.60 (±5.12) years (P = 0.037). Conclusion: This study, which is the first survey of seroprevalence of anti-Zika antibodies from India, reports an overall seropositivity rate of 10% for anti-Zika antibodies among the healthy population, suggesting an ongoing, low level, silent transmission of ZIKV in the local community.https://journals.lww.com/10.4103/ijph.ijph_1098_23antenatal mothersblood donorsepidemiological surveillanceseroprevalencezika virus |
| spellingShingle | Shashwati Nema Dipesh Kale Romesh Jain Ajay Halder Manisha Shrivastava Deepak Vaishnav Ashvini Kumar Yadav Divya Namdeo Debasis Biswas A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central India Indian Journal of Public Health antenatal mothers blood donors epidemiological surveillance seroprevalence zika virus |
| title | A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central India |
| title_full | A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central India |
| title_fullStr | A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central India |
| title_full_unstemmed | A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central India |
| title_short | A Pilot Seroprevalence Study Suggests Silent Zika virus Transmission in Bhopal Region of Central India |
| title_sort | pilot seroprevalence study suggests silent zika virus transmission in bhopal region of central india |
| topic | antenatal mothers blood donors epidemiological surveillance seroprevalence zika virus |
| url | https://journals.lww.com/10.4103/ijph.ijph_1098_23 |
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