Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis
A 43-year-old man with linear immunoglobulin A (IgA) dermatosis associated with gluten intolerance presented with progressive vision loss, pain and photosensitivity in both eyes. His visual acuity was light perception (LP) in both eyes. A physical examination revealed bullous, papular lesions with e...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2010/280396 |
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| author | Cinthya Ramos-Castellón Gabriela Ortiz-Nieva Fernando Fresán Leonardo Villalvazo Yonathan Garfias Alejandro Navas María C. Jiménez-Martínez |
| author_facet | Cinthya Ramos-Castellón Gabriela Ortiz-Nieva Fernando Fresán Leonardo Villalvazo Yonathan Garfias Alejandro Navas María C. Jiménez-Martínez |
| author_sort | Cinthya Ramos-Castellón |
| collection | DOAJ |
| description | A 43-year-old man with linear immunoglobulin A (IgA) dermatosis associated with gluten intolerance presented with progressive vision loss, pain and photosensitivity in both eyes. His visual acuity was light perception (LP) in both eyes. A physical examination revealed bullous, papular lesions with erythematous borders in periocular tissues, limbs, and thorax. Slit-lamp examination showed conjunctival hyperemia, fibrosis, corneal opacification, and vascularization with epithelial defects. Immunofluorescent skin and corneal surface biopsy studies showed linear IgA deposits. The patient was treated with keratolimbal allogenic transplantation and cryopreserved amniotic membrane in the right eye. Regardless of the treatment he persisted with torpid evolution developing retinal and choroidal detachments. After these events he was started on intravenous immune globulin (IVIG) and showed very slight improvement in ocular surface. These types of blistering diseases are rare in the eye. Even when adequate local treatment is given, systemic treatment is mandatory and ocular prognosis can be unsatisfactory. |
| format | Article |
| id | doaj-art-e7d7eec88d42460998bac7989df808b1 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-e7d7eec88d42460998bac7989df808b12025-02-03T01:06:43ZengWileyJournal of Ophthalmology2090-004X2090-00582010-01-01201010.1155/2010/280396280396Ocular Involvement and Blindness Secondary to Linear IgA DermatosisCinthya Ramos-Castellón0Gabriela Ortiz-Nieva1Fernando Fresán2Leonardo Villalvazo3Yonathan Garfias4Alejandro Navas5María C. Jiménez-Martínez6Department of Cornea and Refractive Surgery, Institute of Ophthalmology “Conde de Valenciana”, 06800 Mexico City, DF, MexicoDepartment of Cornea and Refractive Surgery, Institute of Ophthalmology “Conde de Valenciana”, 06800 Mexico City, DF, MexicoDepartment of Dermatology, Institute of Ophthalmology “Conde de Valenciana”, 06800 Mexico City, DF, MexicoDepartment of Pathology, Institute of Ophthalmology “Conde de Valenciana”, 06800 Mexico City, DF, MexicoDepartment of Immunology and Research Unit, Institute of Ophthalmology “Conde de Valenciana”, 06800 Mexico City, DF, MexicoDepartment of Cornea and Refractive Surgery, Institute of Ophthalmology “Conde de Valenciana”, 06800 Mexico City, DF, MexicoDepartment of Immunology and Research Unit, Institute of Ophthalmology “Conde de Valenciana”, 06800 Mexico City, DF, MexicoA 43-year-old man with linear immunoglobulin A (IgA) dermatosis associated with gluten intolerance presented with progressive vision loss, pain and photosensitivity in both eyes. His visual acuity was light perception (LP) in both eyes. A physical examination revealed bullous, papular lesions with erythematous borders in periocular tissues, limbs, and thorax. Slit-lamp examination showed conjunctival hyperemia, fibrosis, corneal opacification, and vascularization with epithelial defects. Immunofluorescent skin and corneal surface biopsy studies showed linear IgA deposits. The patient was treated with keratolimbal allogenic transplantation and cryopreserved amniotic membrane in the right eye. Regardless of the treatment he persisted with torpid evolution developing retinal and choroidal detachments. After these events he was started on intravenous immune globulin (IVIG) and showed very slight improvement in ocular surface. These types of blistering diseases are rare in the eye. Even when adequate local treatment is given, systemic treatment is mandatory and ocular prognosis can be unsatisfactory.http://dx.doi.org/10.1155/2010/280396 |
| spellingShingle | Cinthya Ramos-Castellón Gabriela Ortiz-Nieva Fernando Fresán Leonardo Villalvazo Yonathan Garfias Alejandro Navas María C. Jiménez-Martínez Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis Journal of Ophthalmology |
| title | Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis |
| title_full | Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis |
| title_fullStr | Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis |
| title_full_unstemmed | Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis |
| title_short | Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis |
| title_sort | ocular involvement and blindness secondary to linear iga dermatosis |
| url | http://dx.doi.org/10.1155/2010/280396 |
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