Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer’s disease

Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer’s disease

Abstract Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimer’s disease through untargeted metabolomics...

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Bibliographic Details
Main Authors: S. Amrutha, Chandran S. Abhinand, Shubham Sukerndeo Upadhyay, Ravishankar Parvaje, Thottethodi Subrahmanya Keshava Prasad, Prashant Kumar Modi
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Tinospora cordifolia
Medhya rasayana
Untargeted metabolomics
Neuroprotection
Therapeutic targets
Online Access:https://doi.org/10.1038/s41598-025-92756-5
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https://doi.org/10.1038/s41598-025-92756-5

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