Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation
Angiogenesis is a complex physiological process. In recent years, the immune regulation of angiogenesis has received increasing attention, and innate immune cells, which are centred on macrophages, are thought to play important roles in vascular neogenesis and development. Various innate immune cell...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2453826 |
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| author | Jinjing Wu Yulu Qian Kuang Yang Shuhua Zhang Erming Zeng Daya Luo |
| author_facet | Jinjing Wu Yulu Qian Kuang Yang Shuhua Zhang Erming Zeng Daya Luo |
| author_sort | Jinjing Wu |
| collection | DOAJ |
| description | Angiogenesis is a complex physiological process. In recent years, the immune regulation of angiogenesis has received increasing attention, and innate immune cells, which are centred on macrophages, are thought to play important roles in vascular neogenesis and development. Various innate immune cells can act on the vasculature through a variety of mechanisms, with commonalities as well as differences and synergistic effects, which are crucial for the progression of vascular lesions. In recent years, monotherapy with antiangiogenic drugs has encountered therapeutic bottlenecks because of the short-term effect of ‘vascular normalization’. The combination treatment of antiangiogenic therapy and immunotherapy breaks the traditional treatment pattern. While it has a remarkable curative effect and survival benefits, it also faces many challenges. This review focuses on innate immune cells and mainly introduces the regulatory mechanisms of monocytes, macrophages, natural killer (NK) cells, dendritic cells (DCs) and neutrophils in vascular lesions. The purpose of this paper was to elucidate the underlying mechanisms of angiogenesis and development and the current research status of innate immune cells in regulating vascular lesions in different states. This review provides a theoretical basis for addressing aberrant angiogenesis in disease processes or finding new antiangiogenic immune targets in inflammation and tumor. |
| format | Article |
| id | doaj-art-e7c92349e10246548af7d9a110c70c6e |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-e7c92349e10246548af7d9a110c70c6e2025-01-23T16:36:29ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2453826Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulationJinjing Wu0Yulu Qian1Kuang Yang2Shuhua Zhang3Erming Zeng4Daya Luo5School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaQueen Mary University of London, Nanchang University, Nanchang, ChinaJiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Jiangxi Cardiovascular Research Institute, Nanchang, Jiangxi, ChinaDepartment of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaAngiogenesis is a complex physiological process. In recent years, the immune regulation of angiogenesis has received increasing attention, and innate immune cells, which are centred on macrophages, are thought to play important roles in vascular neogenesis and development. Various innate immune cells can act on the vasculature through a variety of mechanisms, with commonalities as well as differences and synergistic effects, which are crucial for the progression of vascular lesions. In recent years, monotherapy with antiangiogenic drugs has encountered therapeutic bottlenecks because of the short-term effect of ‘vascular normalization’. The combination treatment of antiangiogenic therapy and immunotherapy breaks the traditional treatment pattern. While it has a remarkable curative effect and survival benefits, it also faces many challenges. This review focuses on innate immune cells and mainly introduces the regulatory mechanisms of monocytes, macrophages, natural killer (NK) cells, dendritic cells (DCs) and neutrophils in vascular lesions. The purpose of this paper was to elucidate the underlying mechanisms of angiogenesis and development and the current research status of innate immune cells in regulating vascular lesions in different states. This review provides a theoretical basis for addressing aberrant angiogenesis in disease processes or finding new antiangiogenic immune targets in inflammation and tumor.https://www.tandfonline.com/doi/10.1080/07853890.2025.2453826Innate immune cellsangiogenesisvascular lesionimmune regulationimmunotherapy |
| spellingShingle | Jinjing Wu Yulu Qian Kuang Yang Shuhua Zhang Erming Zeng Daya Luo Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation Annals of Medicine Innate immune cells angiogenesis vascular lesion immune regulation immunotherapy |
| title | Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation |
| title_full | Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation |
| title_fullStr | Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation |
| title_full_unstemmed | Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation |
| title_short | Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation |
| title_sort | innate immune cells in vascular lesions mechanism and significance of diversified immune regulation |
| topic | Innate immune cells angiogenesis vascular lesion immune regulation immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2453826 |
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