Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts

Abstract Background The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. These effects include differences in DNA methylation...

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Main Authors: Seyma Katrinli, Agaz H. Wani, Adam X. Maihofer, Andrew Ratanatharathorn, Nikolaos P. Daskalakis, Janitza Montalvo-Ortiz, Diana L. Núñez-Ríos, Anthony S. Zannas, Xiang Zhao, Allison E. Aiello, Allison E. Ashley-Koch, Diana Avetyan, Dewleen G. Baker, Jean C. Beckham, Marco P. Boks, Leslie A. Brick, Evelyn Bromet, Frances A. Champagne, Chia-Yen Chen, Shareefa Dalvie, Michelle F. Dennis, Segun Fatumo, Catherine Fortier, Sandro Galea, Melanie E. Garrett, Elbert Geuze, Gerald Grant, Michael A. Hauser, Jasmeet P. Hayes, Sian M. J. Hemmings, Bertrand Russel Huber, Aarti Jajoo, Stefan Jansen, Ronald C. Kessler, Nathan A. Kimbrel, Anthony P. King, Joel E. Kleinman, Nastassja Koen, Karestan C. Koenen, Pei-Fen Kuan, Israel Liberzon, Sarah D. Linnstaedt, Adriana Lori, Benjamin J. Luft, Jurjen J. Luykx, Christine E. Marx, Samuel A. McLean, Divya Mehta, William Milberg, Mark W. Miller, Mary S. Mufford, Clarisse Musanabaganwa, Jean Mutabaruka, Leon Mutesa, Charles B. Nemeroff, Nicole R. Nugent, Holly K. Orcutt, Xue-Jun Qin, Sheila A. M. Rauch, Kerry J. Ressler, Victoria B. Risbrough, Eugène Rutembesa, Bart P. F. Rutten, Soraya Seedat, Dan J. Stein, Murray B. Stein, Sylvanus Toikumo, Robert J. Ursano, Annette Uwineza, Mieke H. Verfaellie, Eric Vermetten, Christiaan H. Vinkers, Erin B. Ware, Derek E. Wildman, Erika J. Wolf, Ross McD Young, Ying Zhao, Leigh L. van den Heuvel, PGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research Group, Monica Uddin, Caroline M. Nievergelt, Alicia K. Smith, Mark W. Logue
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Medicine
Subjects:
PTSD
Trauma
DNA methylation
Postmortem brain
GWAS
Gene expression
Online Access:https://doi.org/10.1186/s13073-024-01417-1
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