Effects of Early Training and Nicotine Treatment on the Performance of Male NMRI Mice in the Water Maze
This research aimed to evaluate the effect of nicotine treatment and prior training on a spatial learning task in differently aged NMRI male mice. In a longitudinal study, mice were randomly assigned to one of 14 experimental groups receiving different combinations of chronically injected nicotine (...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2003.303 |
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| Summary: | This research aimed to evaluate the effect of
nicotine treatment and prior training on a
spatial learning task in differently aged NMRI
male mice. In a longitudinal study, mice were
randomly assigned to one of 14 experimental
groups receiving different combinations of
chronically injected nicotine (0.35 mg/kg)
administered for 10 days (5 days before and
during 5 days acquisition of task) or control
treatments and training in the water maze at
different ages. The mice displayed shorter
escape latencies when evaluated at 6 and 10
months than when tested in this task at 2
months for the first time, demonstrating that
early training preserves performance in the
water maze up to 8 months after the initial
experience. Nicotine treatment did not
significantly change performance in the water
maze at any age tested. Early practice in a
spatial reference memory task appears to have
lasting consequences and can potentially
contribute to preventing some age-related
spatial learning deficits. |
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| ISSN: | 2090-5904 1687-5443 |