Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/239691 |
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| author | Diletta Bonciani Alice Verdelli Veronica Bonciolini Antonietta D'Errico Emiliano Antiga Paolo Fabbri Marzia Caproni |
| author_facet | Diletta Bonciani Alice Verdelli Veronica Bonciolini Antonietta D'Errico Emiliano Antiga Paolo Fabbri Marzia Caproni |
| author_sort | Diletta Bonciani |
| collection | DOAJ |
| description | Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions. |
| format | Article |
| id | doaj-art-e7bc0cc0b13a4b079a233a7c4a2fd92d |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e7bc0cc0b13a4b079a233a7c4a2fd92d2025-02-03T01:27:17ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/239691239691Dermatitis Herpetiformis: From the Genetics to the Development of Skin LesionsDiletta Bonciani0Alice Verdelli1Veronica Bonciolini2Antonietta D'Errico3Emiliano Antiga4Paolo Fabbri5Marzia Caproni6Section of Dermatology, Department of Medical and Surgical Clinical Care, University of Florence, 50129 Florence, ItalySection of Dermatology, Department of Medical and Surgical Clinical Care, University of Florence, 50129 Florence, ItalySection of Dermatology, Department of Medical and Surgical Clinical Care, University of Florence, 50129 Florence, ItalySection of Dermatology, Department of Medical and Surgical Clinical Care, University of Florence, 50129 Florence, ItalySection of Dermatology, Department of Medical and Surgical Clinical Care, University of Florence, 50129 Florence, ItalySection of Dermatology, Department of Medical and Surgical Clinical Care, University of Florence, 50129 Florence, ItalySection of Dermatology, Department of Medical and Surgical Clinical Care, University of Florence, 50129 Florence, ItalyDermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions.http://dx.doi.org/10.1155/2012/239691 |
| spellingShingle | Diletta Bonciani Alice Verdelli Veronica Bonciolini Antonietta D'Errico Emiliano Antiga Paolo Fabbri Marzia Caproni Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions Clinical and Developmental Immunology |
| title | Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions |
| title_full | Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions |
| title_fullStr | Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions |
| title_full_unstemmed | Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions |
| title_short | Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions |
| title_sort | dermatitis herpetiformis from the genetics to the development of skin lesions |
| url | http://dx.doi.org/10.1155/2012/239691 |
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