Targeting RNA splicing modulation: new perspectives for anticancer strategy?
Abstract The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tu...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13046-025-03279-w |
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| _version_ | 1832571205112037376 |
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| author | Xuemei Lv Xiaoyu Sun Yang Gao Xinyue Song Xiaoyun Hu Lang Gong Li Han Miao He Minjie Wei |
| author_facet | Xuemei Lv Xiaoyu Sun Yang Gao Xinyue Song Xiaoyun Hu Lang Gong Li Han Miao He Minjie Wei |
| author_sort | Xuemei Lv |
| collection | DOAJ |
| description | Abstract The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tumors. Therefore, identifying cancer-specific subtypes from aberrant processing offers new opportunities for therapeutic development. Numerous splicing modulators, each utilizing different mechanisms, have been developed as promising anticancer therapies, some of which are in clinical trials. In this review, we summarize the splice-altered signatures of cancer cell transcriptomes and the contributions of splicing aberrations to tumorigenesis and progression. Especially, we discuss current and emerging RNA splicing-targeted strategies for cancer therapy, including pharmacological approaches and splice-switching antisense oligonucleotides (ASOs). Finally, we address the challenges and opportunities in translating these findings into clinical practice. |
| format | Article |
| id | doaj-art-e7b8934eea404f749e0a56f0f0dc427d |
| institution | Kabale University |
| issn | 1756-9966 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj-art-e7b8934eea404f749e0a56f0f0dc427d2025-02-02T12:47:45ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662025-01-0144112210.1186/s13046-025-03279-wTargeting RNA splicing modulation: new perspectives for anticancer strategy?Xuemei Lv0Xiaoyu Sun1Yang Gao2Xinyue Song3Xiaoyun Hu4Lang Gong5Li Han6Miao He7Minjie Wei8Department of Pharmacology, School of Pharmacy, China Medical UniversityDepartment of Pharmacology, School of Pharmacy, China Medical UniversityDepartment of Pharmacology, School of Pharmacy, China Medical UniversityDepartment of Pharmacology, School of Pharmacy, China Medical UniversityScientific Experimental Center, School of Pharmacy, China Medical UniversityDepartment of Pharmacology, School of Pharmacy, China Medical UniversityDepartment of Pharmacology, School of Pharmacy, China Medical UniversityDepartment of Pharmacology, School of Pharmacy, China Medical UniversityDepartment of Pharmacology, School of Pharmacy, China Medical UniversityAbstract The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tumors. Therefore, identifying cancer-specific subtypes from aberrant processing offers new opportunities for therapeutic development. Numerous splicing modulators, each utilizing different mechanisms, have been developed as promising anticancer therapies, some of which are in clinical trials. In this review, we summarize the splice-altered signatures of cancer cell transcriptomes and the contributions of splicing aberrations to tumorigenesis and progression. Especially, we discuss current and emerging RNA splicing-targeted strategies for cancer therapy, including pharmacological approaches and splice-switching antisense oligonucleotides (ASOs). Finally, we address the challenges and opportunities in translating these findings into clinical practice.https://doi.org/10.1186/s13046-025-03279-wCancerAlternative splicingSplicing modulatorsSplice-switching ASOTargeted therapy |
| spellingShingle | Xuemei Lv Xiaoyu Sun Yang Gao Xinyue Song Xiaoyun Hu Lang Gong Li Han Miao He Minjie Wei Targeting RNA splicing modulation: new perspectives for anticancer strategy? Journal of Experimental & Clinical Cancer Research Cancer Alternative splicing Splicing modulators Splice-switching ASO Targeted therapy |
| title | Targeting RNA splicing modulation: new perspectives for anticancer strategy? |
| title_full | Targeting RNA splicing modulation: new perspectives for anticancer strategy? |
| title_fullStr | Targeting RNA splicing modulation: new perspectives for anticancer strategy? |
| title_full_unstemmed | Targeting RNA splicing modulation: new perspectives for anticancer strategy? |
| title_short | Targeting RNA splicing modulation: new perspectives for anticancer strategy? |
| title_sort | targeting rna splicing modulation new perspectives for anticancer strategy |
| topic | Cancer Alternative splicing Splicing modulators Splice-switching ASO Targeted therapy |
| url | https://doi.org/10.1186/s13046-025-03279-w |
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