Gestational hypertension: fetal and placental characterization using MRI and ultrasound
Objectives This study aims to integrate MRI and ultrasound (US) assessments of fetal and placental growth and development in cases of gestational hypertension (GH), evaluating their potential utility for clinical management and prognostic evaluation.Methods A retrospective study analyzed 84 pregnant...
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Taylor & Francis Group
2025-12-01
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| Series: | The Journal of Maternal-Fetal & Neonatal Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/14767058.2025.2521796 |
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| author | Junqin Zhang Xue Tang Zhongxiang Ding Fangmei Zhu |
| author_facet | Junqin Zhang Xue Tang Zhongxiang Ding Fangmei Zhu |
| author_sort | Junqin Zhang |
| collection | DOAJ |
| description | Objectives This study aims to integrate MRI and ultrasound (US) assessments of fetal and placental growth and development in cases of gestational hypertension (GH), evaluating their potential utility for clinical management and prognostic evaluation.Methods A retrospective study analyzed 84 pregnant women (39 with GH, 45 controls) to compare fetal and placental parameters using MRI and US. Parameters included placental thickness (PT), relative signal intensity(rSI), relative apparent diffusion coefficient(rADC), lung-to-liver signal intensity ratio(LLSIR), and various indices of the umbilical and middle cerebral arteries. Differences between the GH and control groups were statistically examined. Binary logistic regression identified independent risk factors for GH-related adverse outcomes, leading to the creation of predictive models (MRI-only, US-only, and MRI+US). ROC curves assessed each model’s predictive performance, and the DeLong test compared the area under the curve (AUC) among models.Results In comparison to the control group, the GH group showed: 1) Increased PT thickness and decreased rSI and rADC values (p < 0.05). 2) Higher vascular resistance, as indicated by significantly elevated systolic-diastolic ratio (UA-S/D ratio), pulsatility index (UA-PI), and resistance index (UA-RI) of the umbilical artery (all p < 0.05), was observed. 3) Shorter biparietal diameter (BPD, p < 0.05) and reduced LLSIR (p < 0.001). 4) UA-PI, UA-S/D, PT, rADC, and rSI were identified as independent risk factors for GH through binary logistic regression. ROC analysis demonstrated that the MRI+US model (AUC = 0.89, sensitivity = 85%, specificity = 93%) significantly improved the prediction accuracy, with the combined model’s AUC value being significantly different from other models (p < 0.05).Conclusions The integration of MRI and US offers a robust evaluation of placental and fetal growth and development in GH patients. Furthermore, the combined utilization of MRI and US techniques exhibits enhanced accuracy in predicting adverse pregnancy outcomes. |
| format | Article |
| id | doaj-art-e7b2a1cb3a30445bb6f5b5f7e27ae4d6 |
| institution | DOAJ |
| issn | 1476-7058 1476-4954 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | The Journal of Maternal-Fetal & Neonatal Medicine |
| spelling | doaj-art-e7b2a1cb3a30445bb6f5b5f7e27ae4d62025-08-20T03:16:17ZengTaylor & Francis GroupThe Journal of Maternal-Fetal & Neonatal Medicine1476-70581476-49542025-12-0138110.1080/14767058.2025.2521796Gestational hypertension: fetal and placental characterization using MRI and ultrasoundJunqin Zhang0Xue Tang1Zhongxiang Ding2Fangmei Zhu3The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, ChinaThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaObjectives This study aims to integrate MRI and ultrasound (US) assessments of fetal and placental growth and development in cases of gestational hypertension (GH), evaluating their potential utility for clinical management and prognostic evaluation.Methods A retrospective study analyzed 84 pregnant women (39 with GH, 45 controls) to compare fetal and placental parameters using MRI and US. Parameters included placental thickness (PT), relative signal intensity(rSI), relative apparent diffusion coefficient(rADC), lung-to-liver signal intensity ratio(LLSIR), and various indices of the umbilical and middle cerebral arteries. Differences between the GH and control groups were statistically examined. Binary logistic regression identified independent risk factors for GH-related adverse outcomes, leading to the creation of predictive models (MRI-only, US-only, and MRI+US). ROC curves assessed each model’s predictive performance, and the DeLong test compared the area under the curve (AUC) among models.Results In comparison to the control group, the GH group showed: 1) Increased PT thickness and decreased rSI and rADC values (p < 0.05). 2) Higher vascular resistance, as indicated by significantly elevated systolic-diastolic ratio (UA-S/D ratio), pulsatility index (UA-PI), and resistance index (UA-RI) of the umbilical artery (all p < 0.05), was observed. 3) Shorter biparietal diameter (BPD, p < 0.05) and reduced LLSIR (p < 0.001). 4) UA-PI, UA-S/D, PT, rADC, and rSI were identified as independent risk factors for GH through binary logistic regression. ROC analysis demonstrated that the MRI+US model (AUC = 0.89, sensitivity = 85%, specificity = 93%) significantly improved the prediction accuracy, with the combined model’s AUC value being significantly different from other models (p < 0.05).Conclusions The integration of MRI and US offers a robust evaluation of placental and fetal growth and development in GH patients. Furthermore, the combined utilization of MRI and US techniques exhibits enhanced accuracy in predicting adverse pregnancy outcomes.https://www.tandfonline.com/doi/10.1080/14767058.2025.2521796Gestational hypertensionfetusplacentaMR imagingUltrasound |
| spellingShingle | Junqin Zhang Xue Tang Zhongxiang Ding Fangmei Zhu Gestational hypertension: fetal and placental characterization using MRI and ultrasound The Journal of Maternal-Fetal & Neonatal Medicine Gestational hypertension fetus placenta MR imaging Ultrasound |
| title | Gestational hypertension: fetal and placental characterization using MRI and ultrasound |
| title_full | Gestational hypertension: fetal and placental characterization using MRI and ultrasound |
| title_fullStr | Gestational hypertension: fetal and placental characterization using MRI and ultrasound |
| title_full_unstemmed | Gestational hypertension: fetal and placental characterization using MRI and ultrasound |
| title_short | Gestational hypertension: fetal and placental characterization using MRI and ultrasound |
| title_sort | gestational hypertension fetal and placental characterization using mri and ultrasound |
| topic | Gestational hypertension fetus placenta MR imaging Ultrasound |
| url | https://www.tandfonline.com/doi/10.1080/14767058.2025.2521796 |
| work_keys_str_mv | AT junqinzhang gestationalhypertensionfetalandplacentalcharacterizationusingmriandultrasound AT xuetang gestationalhypertensionfetalandplacentalcharacterizationusingmriandultrasound AT zhongxiangding gestationalhypertensionfetalandplacentalcharacterizationusingmriandultrasound AT fangmeizhu gestationalhypertensionfetalandplacentalcharacterizationusingmriandultrasound |